ArticleCaspian journal of internal medicine2015
Isolated thrombocytopenia; A report of a rare presentation of childhood systemic lupus erythematosus (SLE).
Article in Caspian journal of internal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- [Untargeted metabolomics reveals differential serum metabolites and metabolic pathways in patients with primary Sjögren syndrome and thrombocytopenia].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- Isolated thrombocytopenia as the initial manifestation of childhood-onset systemic lupus erythematosus: A case report.Medicine · 2025Article
- Severe Thrombocytopenia as the Main Manifestation of Childhood-Onset Systemic Lupus Erythematosus.Mediterranean journal of rheumatology · 2022Article
- Immune Thrombocytopenic Purpura as Initial Presentation of Paediatric SLE: A Case Report.JNMA; journal of the Nepal Medical Association · 2021Article
- Outcomes in Mild to Moderate Isolated Thrombocytopenia.Pediatrics · 2018Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundSystemic lupus erythematosus (SLE) has various presentations in children. Hematologic abnormalities is common in childhood onset of SLE, however, isolated thrombocytopenia is relatively rare. Thus, we present a child with isolated thrombocytopenia as a rare presentation of SLE. CASE PRESENTATION: A 12-year-old boy with chief complaints of loss of appetite, weight loss, decreased platelet count (8000/µL) and lymph node enlargement was referred to our hospital. Biopsy of lymph node showed reactive lymphadenopathy. Investigations regarding infectious disease was negative. Platelet count remained low after low dose steroidned therapy. Antinuclear antibody (ANA) and anti-double stranded DNA antibody screening tests were positive with titer of 1/62 and 1/54, respectively. Therefore, juvenile SLE was considered as the final diagnosis and raising the dose of prednisolone to 2mg/kg/day was associated with increasing platelet count to 40000/µL and a week later to 96000/µL.
conclusionThe findings of this study indicate that in cases with isolated thrombocytopenia refractory to conventional dose of steroids, SLE should be considered. This study justifies serum ANA and anti DNA assessment in children with thrombocytopenia.
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