ArticleInternational journal of fertility & sterility
Chromosomal Aneuploidies and Early Embryonic Developmental Arrest.
Article in International journal of fertility & sterility. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular Drivers of Developmental Arrest in the Human Preimplantation Embryo: A Systematic Review and Critical Analysis Leading to Mapping Future Research.International journal of molecular sciences · 2021Pooled it
- Abnormal cleavage patterns in equine in vitro-produced embryos lead to higher early pregnancy loss.Equine veterinary journal · 2026Article
- Identification of chromosomal abnormalities in miscarriages using single-nucleotide polymorphism arrays.Archives of gynecology and obstetrics · 2026Article
- Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.International journal of molecular sciences · 2026Review
- Approximate Bayesian computation supports a high incidence of chromosomal mosaicism in blastocyst-stage human embryos.Genetics · 2025Article
- Approximate Bayesian computation supports a high incidence of chromosomal mosaicism in blastocyst-stage human embryos.bioRxiv : the preprint server for biology · 2025Article
- Single-cell multi-omics profiling of human preimplantation embryos identifies cytoskeletal defects during embryonic arrest.Nature cell biology · 2024Article
- Meiotic and mitotic aneuploidies drive arrest of in vitro fertilized human preimplantation embryos.Genome medicine · 2023Article
- Human embryos derived from first polar body nuclear transfer exhibit comparatively abnormal morphokinetics during development.Clinical and experimental reproductive medicine · 2023Article
- Exogenous L-Glutathione Improves Vitrification Outcomes in Murine Preimplantation Embryos.Antioxidants (Basel, Switzerland) · 2022Article
- The association between essential trace element (copper, zinc, selenium, and cobalt) status and the risk of early embryonic arrest among women undergoing assisted reproductive techniques.Frontiers in endocrinology · 2022Article
- Competence of embryos showing transient developmental arrest during in vitro culture.Journal of assisted reproduction and genetics · 2021Article
- Association between mild stimulated IVF/M cycle and early embryo arrest in sub fertile women with/without PCOS.Reproductive biology and endocrinology : RB&E · 2020Article
- Concordance of various chromosomal errors among different parts of the embryo and the value of re-biopsy in embryos with segmental aneuploidies.Molecular human reproduction · 2020Article
- Molecular signatures of aneuploidy-driven adaptive evolution.Nature communications · 2020Article
- Cellular Fragments in the Perivitelline Space Are Not a Predictor of Expanded Blastocyst Quality.Frontiers in cell and developmental biology · 2020Article
- Human germline genome editing.Nature cell biology · 2019Review
- Concordance between different trophectoderm biopsy sites and the inner cell mass of chromosomal composition measured with a next-generation sequencing platform.Molecular human reproduction · 2018Article
- Contraction behaviour reduces embryo competence in high-quality euploid blastocysts.Journal of assisted reproduction and genetics · 2018Article
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSelecting the best embryo for transfer, with the highest chance of achieving a vital pregnancy, is a major goal in current in vitro fertilization (IVF) technology. The high rate of embryonic developmental arrest during IVF treatment is one of the limitations in achieving this goal. Chromosomal abnormalities are possibly linked with chromosomal arrest and selection against abnormal fertilization products. The objective of this study was to evaluate the frequency and type of chromosomal abnormalities in preimplantation embryos with developmental arrest. MATERIALS AND
methodsThis cohort study included blastomeres of embryos with early developmental arrest that were biopsied and analyzed by fluorescence in-situ hybridization (FISH) with probes for chromosomes 13, 16, 18, 21 and 22. Forty-five couples undergoing IVF treatment were included, and 119 arrested embryos were biopsied. All probes were obtained from the Kinderwunsch Zentrum, Linz, Austria, between August 2009 and August 2011.
resultsOf these embryos, 31.6% were normal for all chromosomes tested, and 68.4% were abnormal. Eleven embryos were uniformly aneuploid, 20 were polyploid, 3 were haploid, 11 displayed mosaicism and 22 embryos exhibited chaotic chromosomal complement.
conclusionNearly 70% of arrested embryos exhibit chromosomal errors, making chromosomal abnormalities a major cause of embryonic arrest and may be a further explanation for the high developmental failure rates during culture of the embryos in the IVF setting.
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