ArticleJournal of clinical and experimental dentistry2015
Inmunohistochemical detection of mastocytes in tissue from patients with actinic prurigo.
Article in Journal of clinical and experimental dentistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Refractory pediatric actinic prurigo successfully treated with upadacitinib: A case report.SAGE open medical case reports · 2025Article
- The Immunogenetics of Photodermatoses.Advances in experimental medicine and biology · 2022Article
- Value of the toluidine blue test as an aid to determine the biopsy site in actinic prurigo cheilitis.Autopsy & case reports · 2021Article
- Actinic prurigo in a dermatological reference center in Colombia: 108 casesBiomedica : revista del Instituto Nacional de Salud · 2020Observational
- Correlation of serum IgE levels and clinical manifestations in patients with actinic prurigo.Anais brasileiros de dermatologiaArticle
- Risk factors associated with actinic prurigo: a case control study.Anais brasileiros de dermatologiaArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundActinic prurigo (AP) is a type of photodermatosis, the pathophysiology of which has not been determined. AP has been suggested to be a hypersensitivity reaction to the presence of eosinophils and the local production of IgE. MATERIAL AND
methodsDescriptive study, using paraffin blocks of tissue that have been diagnosed with AP from the Dermopathology department, Hospital General Dr. Manuel Gea González. In 66 blocks from 63 patients, eosinophils were identified by hematoxylin and eosin staining, and mastocytes were labeled by immunohistochemistry. Three random microphotographs (40x) were used, and cell counts were calculated as the mean count in the 3 microphotographs.
resultsForty cases (63.5%) were female, and 23 (36.5%) were male. The mean age was 26.49 ±14.09 years; regarding the evolution time of the disease, the average was 11.93 years ±11.39. In 38 of 63 cases (60%), the lip, skin, and conjunctiva were affected clinically. In 22 of 63 cases (34%), AP cheilitis was the sole manifestation, and in 4 of 63 cases (6%), there were lesions in the skin and conjunctiva. The mean eosinophil count was 9 per case, the average number of mastocytes/field was 28.48 (range 0 to 66) Kruskal-Wallis p=0.001.
conclusionsThere are elements in AP that mediate the reaction of hypersensitivity type IV b, necessitating the identification of triggering factors. KEY WORDS: Actinic prurigo, eosinophil, hypersensitivity IV b, IgE, mastocytes.
Identifiers
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Registered trials
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