Evidence map›Paper›PMID 26644841›Full record

ArticleJournal of clinical and experimental dentistry2015

Moxifloxacin versus Clindamycin/Ceftriaxone in the management of odontogenic maxillofacial infectious processes: A preliminary, intrahospital, controlled clinical trial.

Hansel Gómez-Arámbula, Antonio Hidalgo-Hurtado, Rosaura Rodríguez-Flores, Ana-María González-Amaro, Arturo Garrocho-Rangel, Amaury Pozos-Guillén

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental dentistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05027893 (Efficacy of the Application of Moxifloxacin and Cefixime in Reduction of Inflammatory Sequelae and Complications After Mandibular Third Molar Surgery), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05027893 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Efficacy of the Application of Moxifloxacin and Cefixime in Reduction of Inflammatory Sequelae and Complications After Mandibular Third Molar Surgery

TypeinterventionalSponsorUniversity of Novi SadRan2019 to 2023Enrolled157ConditionsPostoperative Complications, Antibiotic Reaction, Antibiotic Side Effect, Antibiotic Resistant InfectionArmsMoxifloxacin 400 mg Oral Tablet, Cefixime 400 mg Oral Tablet, Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hansel Gómez-ArámbulaDDS, Resident, Department of Orofacial Surgery; Hospital "Ignacio Morones Prieto", San Luis Potosi, SLP, Mexico.
Antonio Hidalgo-HurtadoDDS, Associate Professor, Department of Orofacial Surgery; Hospital "Ignacio Morones Prieto", San Luis Potosi, SLP, Mexico.
Rosaura Rodríguez-FloresDDS, Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, SLP, Mexico.
Ana-María González-AmaroMS, Associate Professor, Biochemistry and Microbiology Laboratory, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, SLP, Mexico.
Arturo Garrocho-RangelDDS, MS, PhD, Associate Professor, Basic Sciencies Laboratory, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, SLP, Mexico.
Amaury Pozos-GuillénDDS, MS, PhD, Associate Professor, Basic Sciencies Laboratory, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, SLP, Mexico.
Polytechnic University of San Luis Potosí · MXHospital Central Dr. Ignacio Morones Prieto · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to compare the days of hospitalization length between patients treated with Moxifloxacin with that of patients treated with a Clindamycin/Ceftriaxone combination and additionally, to isolate and identify the oral pathogens involved in orofacial odontogenic infections. MATERIAL AND

methodsA pilot-controlled-clinical-trial was carried out on hospitalized patients with cervicofacial odontogenic abscesses or cellulitis, who were randomly asigned to two study groups: 1) patients who received Moxifloxacin, and 2) patients receiving Clindamycin/Ceftriaxone combination. Infiltrate samples were collected through transdermic or transmucosal punction and later cultured on a media specific for aerobic and anaerobic microorganisms. Mean hospitalization duration in days until hospital discharge and susceptibility assessment in rates were established.

resultsMean hospitalization time in days of patients treated with Moxifloxacin was 7.0 ± 1.6 days, while in the Clindamycin/Ceftriaxone group, this was 8.4 ± 1.8 days, although significant difference could not be demonstrated (p=0.074). A total of 43 strains were isolated, all of these Gram-positive. These strains appeared to be highly sensitive to Moxifloxacin (97.5%) and Ceftriaxone (92.5%).

conclusionsMoxifloxacin and Ceftriaxone appear to be potential convenient and rational alternatives to traditional antibiotics, for treating severe odontogenic infections, in conjunction with surgical extraoral incision, debridement, and drainage. KEY WORDS: Orofacial odontogenic infections, antimicrobial susceptibility, antimicrobial resistance.

Identifiers

PMID26644841
PMCPMC4663067
OpenAlexW2403090803

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.