ArticleThe Journal of cell biology2015
Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation.
Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Integrating and Orchestrating Multiple Components of Skeletal Muscle Injury and Regeneration.American journal of physiology. Cell physiology · 2026Article
- The uncoordinated-5 homologue A is a key receptor in netrin-ligand-mediated fast-twitch myotube formation in male mice.Physiological reports · 2026Article
- Aberrant skeletal muscle morphogenesis and myofiber differentiation characterize equine myotonic dystrophy.PloS one · 2026Article
- Muscle fibroblasts and stem cells stimulate motor neurons in an age and exercise-dependent manner.Aging cell · 2025Article
- Inducible deletion of endothelial cell Efnb2 delays capillary regeneration and attenuates myofibre reinnervation following myotoxin injury in mice.The Journal of physiology · 2024Article
- RORα-GABP-TFAM axis alleviates myosteatosis with fatty atrophy through reinforcement of mitochondrial capacity.Journal of cachexia, sarcopenia and muscle · 2024Article
- Sex-specific alteration in human muscle transcriptome with age.GeroScience · 2023Article
- Normal muscle fiber type distribution is recapitulated in aged ephrin-A3American journal of physiology. Cell physiology · 2023Article
- Functionalizing biomaterials to promote neurovascular regeneration following skeletal muscle injury.American journal of physiology. Cell physiology · 2021Review
- Abundant Synthesis of Netrin-1 in Satellite Cell-Derived Myoblasts Isolated from EDL Rather Than Soleus Muscle Regulates Fast-Type Myotube Formation.International journal of molecular sciences · 2021Article
- Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis.Cell death and differentiation · 2020Article
- Developmental neuromuscular synapse elimination: Activity-dependence and potential downstream effector mechanisms.Neuroscience letters · 2020Review
- Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2Developmental cell · 2019Article
- Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Differences in the constituent fiber types contribute to the intermuscular variation in the timing of the developmental synapse elimination.Scientific reports · 2019Article
- [Effects of FTY720-P on EphA2-EphrinA2 bidirectional signaling in osteoclasts].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Article
- Protein arginine methyltransferase expression, localization, and activity during disuse-induced skeletal muscle plasticity.American journal of physiology. Cell physiology · 2018Article
- Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism.The Journal of clinical investigation · 2017Article
- Keep Your Friends Close: Cell-Cell Contact and Skeletal Myogenesis.Cold Spring Harbor perspectives in biology · 2017Review
- Rules of tissue packing involving different cell types: human muscle organization.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Each adult mammalian skeletal muscle has a unique complement of fast and slow myofibers, reflecting patterns established during development and reinforced via their innervation by fast and slow motor neurons. Existing data support a model of postnatal "matching" whereby predetermined myofiber type identity promotes pruning of inappropriate motor axons, but no molecular mechanism has yet been identified. We present evidence that fiber type-specific repulsive interactions inhibit innervation of slow myofibers by fast motor axons during both postnatal maturation of the neuromuscular junction and myofiber reinnervation after injury. The repulsive guidance ligand ephrin-A3 is expressed only on slow myofibers, whereas its candidate receptor, EphA8, localizes exclusively to fast motor endplates. Adult mice lacking ephrin-A3 have dramatically fewer slow myofibers in fast and mixed muscles, and misexpression of ephrin-A3 on fast myofibers followed by denervation/reinnervation promotes their respecification to a slow phenotype. We therefore conclude that Eph/ephrin interactions guide the fiber type specificity of neuromuscular interactions during development and adult life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.