ArticleThe Journal of cell biology2015
The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells.
Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 56 citations in OpenAlex.
- Linking Planar Cell Polarity to Mechanotransduction During Morphogenesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Wnt5a regulates the expression of developmental genes in the adult retina following optic nerve crush injury.Histology and histopathology · 2025Article
- The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture.Nature communications · 2025Article
- Senior-Loken Syndrome: Ocular Perspectives on Genetics, Pathogenesis, and Management.Biomolecules · 2025Review
- Spontaneous Calcium Bursts Organize the Apical Actin Cytoskeleton of Multiciliated Cells.International journal of molecular sciences · 2025Article
- Formation and function of multiciliated cells.The Journal of cell biology · 2024Review
- Deficiency of the Planar Cell Polarity Protein Intu Delays Kidney Repair and Suppresses Renal Fibrosis after Acute Kidney Injury.The American journal of pathology · 2023Article
- Primary cilia and actin regulatory pathways in renal ciliopathies.Frontiers in nephrology · 2023Review
- Article
- Roles of the actin cytoskeleton in ciliogenesis.Journal of cell science · 2022Review
- Exposure to microplastics leads to a defective ovarian function and change in cytoskeleton protein expression in rat.Environmental science and pollution research international · 2022Article
- Microridge-like structures anchor motile cilia.Nature communications · 2022Article
- Structure of the ciliogenesis-associated CPLANE complex.Science advances · 2022Article
- Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery.EMBO reports · 2022Article
- Association of Nephronophthisis 4 genetic variation with cardiorenal syndrome and cardiovascular events in Japanese general population: the Yamagata (Takahata) study.Heart and vessels · 2022Article
- The structure and function of centriolar rootlets.Journal of cell science · 2021Article
- Planar cell polarity pathway in kidney development, function and disease.Nature reviews. Nephrology · 2021Review
- Formin homology domains of Daam1 bind to Fascin and collaboratively promote pseudopodia formation and cell migration in breast cancer.Cell proliferation · 2021Article
- Aquatic models of human ciliary diseases.Genesis (New York, N.Y. : 2000) · 2021Review
- The Biological Significance and Implications of Planar Cell Polarity for Nephrology.Frontiers in physiology · 2021Review
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motile cilia polarization requires intracellular anchorage to the cytoskeleton; however, the molecular machinery that supports this process remains elusive. We report that Inturned plays a central role in coordinating the interaction between cilia-associated proteins and actin-nucleation factors. We observed that knockdown of nphp4 in multiciliated cells of the Xenopus laevis epidermis compromised ciliogenesis and directional fluid flow. Depletion of nphp4 disrupted the subapical actin layer. Comparison to the structural defects caused by inturned depletion revealed striking similarities. Furthermore, coimmunoprecipitation assays demonstrated that the two proteins interact with each other and that Inturned mediates the formation of ternary protein complexes between NPHP4 and DAAM1. Knockdown of daam1, but not formin-2, resulted in similar disruption of the subapical actin web, whereas nphp4 depletion prevented the association of Inturned with the basal bodies. Thus, Inturned appears to function as an adaptor protein that couples cilia-associated molecules to actin-modifying proteins to rearrange the local actin cytoskeleton.
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