Evidence map›Paper›PMID 26644429›Full record

ReviewJournal of bacteriology2015

Yersinia Type III Secretion System Master Regulator LcrF.

Leah Schwiesow, Hanh Lam, Petra Dersch, Victoria Auerbuch

Abstract readReview
In one paragraph

Review in Journal of bacteriology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Anti-infective compounds forSustainable microbiology · 2026
    Review
  7. Article
  8. Temperature Adaptive Biofilm Formation inAntibiotics (Basel, Switzerland) · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. A ParDE toxin-antitoxin system is responsible for the maintenance of theFrontiers in cellular and infection microbiology · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leah SchwiesowDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California, USA.
Hanh LamDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
Petra DerschDepartment of Molecular Infection Biology, Helmholtz Center for Infection Research, Braunschweig, Lower Saxony, Germany petra.dersch@helmholtz-hzi.de vastone@ucsc.edu.
Victoria AuerbuchDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA petra.dersch@helmholtz-hzi.de vastone@ucsc.edu.

Funding

Training Program/Molecular/Cell/Developmental BiologyT32GM008646 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STROME, SUSAN · 1999 to 2018
$3.7M
Host iron availability in the pathogenesis of enteropathogenic YersiniaR21AI099747 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STONE, VICTORIA AUERBUCH · 2012 to 2013
$406k
NIAID NIH HHS R21 AI099747NIAID NIH HHS R21AI099747NIGMS NIH HHS T32 GM008646NIGMS NIH HHS T32GM008646
6 · The paper itself

Abstract

Many Gram-negative pathogens express a type III secretion (T3SS) system to enable growth and survival within a host. The three human-pathogenic Yersinia species, Y. pestis, Y. pseudotuberculosis, and Y. enterocolitica, encode the Ysc T3SS, whose expression is controlled by an AraC-like master regulator called LcrF. In this review, we discuss LcrF structure and function as well as the environmental cues and pathways known to regulate LcrF expression. Similarities and differences in binding motifs and modes of action between LcrF and the Pseudomonas aeruginosa homolog ExsA are summarized. In addition, we present a new bioinformatics analysis that identifies putative LcrF binding sites within Yersinia target gene promoters.

Indexed as

Gene Expression Regulation, BacterialBacterial ProteinsProtein Structure, TertiaryTrans-ActivatorsType III Secretion SystemsYersiniaBacterial ProteinslcrF protein, Yersinia pestisTrans-ActivatorsType III Secretion Systems

Identifiers

PMID26644429
PMCPMC4751813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.