ArticleMolecular and cellular biology2016
Identifying Novel Transcriptional Regulators with Circadian Expression.
Article in Molecular and cellular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Coordination of rhythmic RNA synthesis and degradation orchestrates 24-hour and 12-hour RNA expression patterns in mouse fibroblasts.bioRxiv : the preprint server for biology · 2023Article
- Nutrient-sensitive protein O-GlcNAcylation shapes daily biological rhythms.Open biology · 2022Review
- Translational Regulation of Clock Genes BMAL1 and REV-ERBα by Polyamines.International journal of molecular sciences · 2021Article
- Genome-wide circadian regulation: A unique system for computational biology.Computational and structural biotechnology journal · 2020Review
- Mitotic chromosome binding predicts transcription factor properties in interphase.Nature communications · 2019Article
- Gene networks activated by specific patterns of action potentials in dorsal root ganglia neurons.Scientific reports · 2017Article
- Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells.PloS one · 2017Article
- Systems Biology-Derived Discoveries of Intrinsic Clocks.Frontiers in neurology · 2017Review
- The molecular basis of metabolic cycles and their relationship to circadian rhythms.Nature structural & molecular biology · 2016Review
- Circadian Oscillation of the Lettuce Transcriptome under Constant Light and Light-Dark Conditions.Frontiers in plant science · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organisms adapt their physiology and behavior to the 24-h day-night cycle to which they are exposed. On a cellular level, this is regulated by intrinsic transcriptional-translational feedback loops that are important for maintaining the circadian rhythm. These loops are organized by members of the core clock network, which further regulate transcription of downstream genes, resulting in their circadian expression. Despite progress in understanding circadian gene expression, only a few players involved in circadian transcriptional regulation, including transcription factors, epigenetic regulators, and long noncoding RNAs, are known. Aiming to discover such genes, we performed a high-coverage transcriptome analysis of a circadian time course in murine fibroblast cells. In combination with a newly developed algorithm, we identified many transcription factors, epigenetic regulators, and long intergenic noncoding RNAs that are cyclically expressed. In addition, a number of these genes also showed circadian expression in mouse tissues. Furthermore, the knockdown of one such factor, Zfp28, influenced the core clock network. Mathematical modeling was able to predict putative regulator-effector interactions between the identified circadian genes and may help for investigations into the gene regulatory networks underlying circadian rhythms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.