Evidence map›Paper›PMID 26644336›Full record

ArticleAngewandte Chemie (International ed. in English)2016

Taichunamides: Prenylated Indole Alkaloids from Aspergillus taichungensis (IBT 19404).

Ippei Kagiyama, Hikaru Kato, Tatsuo Nehira, Jens C Frisvad, David H Sherman, Robert M Williams, Sachiko Tsukamoto

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. A monograph ofStudies in mycology · 2022
    Article
  7. Antibacterial spirooxindole alkaloids fromFrontiers in microbiology · 2022
    Article
  8. Article
  9. Article
  10. Modular Approaches to Lankacidin Antibiotics.Journal of the American Chemical Society · 2020
    Article
  11. Article
  12. Review
  13. Classification ofStudies in mycology · 2020
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ippei KagiyamaGraduated School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.
Hikaru KatoGraduated School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.
Tatsuo NehiraGraduated School of Integrated Arts and Sciences, Hiroshima University, 1-7-1 Kagamiyama, Higashi-hiroshima, 739-8521, Japan.
Jens C FrisvadSection for Eukaryotic Biotechnology, Departments of System Biology, Technical University of Denmark, Building 221, 2800, Kongens Lyngby, Denmark.
David H ShermanLife Sciences Institute and Departments of Medicinal Chemistry, Chemistry, Microbiology & Immunology, The University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, 48109-2216, USA.
Robert M WilliamsDepartment of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, CO, 80523, USA.
Sachiko TsukamotoGraduated School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan. sachiko@kumamoto-u.ac.jp.

Funding

TOTAL SYNTHESIS AND BIOSYNTHESIS OF BIOACTIVE SUBSTANCESR01CA070375 · NCI · COLORADO STATE UNIVERSITY-FORT COLLINS · PI SHERMAN, DAVID H, WILLIAMS, ROBERT MICHAEL · 1997 to 2018
$4.4M
NCI NIH HHS R01 CA070375
6 · The paper itself

Abstract

Seven new prenylated indole alkaloids, taichunamides A-G, were isolated from the fungus Aspergillus taichungensis (IBT 19404). Taichunamides A and B contained an azetidine and 4-pyridone units, respectively, and are likely biosynthesized from notoamide S via (+)-6-epi-stephacidin A. Taichunamides C and D contain endoperoxide and methylsulfonyl units, respectively. This fungus produced indole alkaloids containing an anti-bicyclo[2.2.2]diazaoctane core, whereas A. protuberus and A. amoenus produced congeners with a syn-bicyclo[2.2.2]diazaoctane core. Plausible biosynthetic pathways to access these cores within the three species likely arise from an intramolecular hetero Diels-Alder reaction.

Indexed as

AspergillusIndole AlkaloidsPrenylationIndole Alkaloidsalkaloidsbiosynthesiscycloadditionnatural productsstructure elucidation

Identifiers

PMID26644336
PMCPMC4960981

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.