ArticleParkinsonism & related disorders2016
Depression and clinical progression in spinocerebellar ataxias.
Article in Parkinsonism & related disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01060371 (Clinical Research Consortium for the Study of Cerebellar Ataxias), which is not on this map. Cited by 73 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Research Consortium for the Study of Cerebellar Ataxias (CRC-SCA) for the Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias (SCA)
Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Neurocognitive Changes in Spinocerebellar Ataxia Type 3: A Systematic Review with a Narrative Design.Cerebellum (London, England) · 2022Pooled it
- Cerebellar Transcranial Direct Current Stimulation in Spinocerebellar Ataxia Type 3: a Randomized, Double-Blind, Sham-Controlled Trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Trial
- Integrating remote testing and machine learning to identify markers of cerebellar ataxia at home.Communications medicine · 2026Article
- Psychological resilience in patients with Friedreich ataxia: a 6-year longitudinal analysis.Neurological research and practice · 2026Article
- Predictive models for ataxia progression and conversion in spinocerebellar ataxia type 1 and 3.Brain : a journal of neurology · 2026Article
- The Medication Patterns of Spinocerebellar Ataxia Type 3 Mutation Carriers Enrolled in the ESMI Cohort.CNS drugs · 2026Article
- Suicidal Ideation in Spinocerebellar Ataxia.The Journal of neuropsychiatry and clinical neurosciences · 2026Article
- Changes in Gait After Training for Individuals With Cerebellar Ataxia.Archives of rehabilitation research and clinical translation · 2025Article
- Practice Recommendations for Genetic Testing of Ataxias.Annals of clinical and translational neurology · 2025Review
- The cerebellum and psychiatric disorders: unraveling its role in mental health.Arquivos de neuro-psiquiatria · 2025Review
- The Natural History Study and Biomarker Collection of the Clinical Research Consortium for the Study of Cerebellar Ataxia (CRC-SCA).Cerebellum (London, England) · 2025Review
- Impact of rehabilitation on quality of life in patients with degenerative cerebellar ataxias using structural equation modeling.Scientific reports · 2025Article
- Longitudinal description of health-related quality of life and depressive symptoms in polyQ spinocerebellar ataxia patients.Journal of neurology · 2025Article
- Depression and Associated Factors Among Patients with Spinocerebellar Ataxia.Medicina (Kaunas, Lithuania) · 2025Article
- Exploring neuropsychiatric symptoms in Friedreich ataxia.Scientific reports · 2024Article
- The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions.Biomedicines · 2024Review
- Neuropsychiatric Manifestations of Degenerative Cerebellar Ataxia.Brain sciences · 2024Article
- Consensus Paper: Cerebellum and Reward.Cerebellum (London, England) · 2024Review
- Content Validity of the Modified Functional Scale for the Assessment and Rating of Ataxia (f-SARA) Instrument in Spinocerebellar Ataxia.Cerebellum (London, England) · 2024Article
- Factors Influencing Health-Related Quality of Life of Patients with Spinocerebellar Ataxia.Cerebellum (London, England) · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 13 institutions in 2 countries.
Funding
Abstract
backgroundDepression is a common comorbidity in spinocerebellar ataxias (SCAs) but its association with ataxia progression is not well understood.
objectivesTo study the prevalence and influence of depressive symptoms in SCAs.
methodsWe studied 300 participants with SCA 1, 2, 3 and 6 from the Clinical Research Consortium for Spinocerebellar Ataxias (CRC-SCA) and repeatedly measured depressive symptoms by the 9-item Patient Health Questionnaire (PHQ-9) along with other clinical features including ataxia, functional status, and quality of life every 6 months for 2 years. We employed regression models to study the effects of depressive symptoms on clinical progression indexed by Scale for Assessment and Rating of Ataxia (SARA), Unified Huntington's Disease Rating Scale Part IV (UHDRS-IV) and EQ5D after adjusting for age, sex and pathological CAG repeats.
resultsComorbid depression is common in SCAs (26%). Although the baseline prevalence of depression was similar among different SCA types, suicidal ideation was more frequently reported in SCA3 (65%). Depressive symptoms were associated with SARA scores but did not significantly progress over time within 2 years or deteriorate by increased numbers of pathological CAG repeats. The effects of depression on ataxia progression varied across different SCA types. Nevertheless, depression had consistently negative and significant impact on functional status and quality of life in all SCAs, even after accounting for ataxia progression.
conclusionsDepressive symptoms are not simply the consequence of motor disability in SCAs. Comorbid depression per se contributes to different health outcomes and deserves more attention when caring patients with SCAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.