Evidence map›Paper›PMID 26644202›Full record

Trial reportThe pharmacogenomics journal2017

Common variants associated with changes in levels of circulating free fatty acids after administration of glucose-insulin-potassium (GIK) therapy in the IMMEDIATE trial.

K L Ellis, Y Zhou, L Rodriguez-Murillo, J R Beshansky, E Ainehsazan, H P Selker, G S Huggins, L A Cupples, I Peter

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The pharmacogenomics journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00091507 (Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care Trial), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00091507 phase3completednot on this map

Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care Trial

TypeinterventionalSponsorTufts Medical CenterRan2006 to 2012Enrolled911ConditionsAngina, Unstable, Cardiovascular Diseases, Heart Diseases, Coronary DiseaseArmsGIK, Placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart.Trends in endocrinology and metabolism: TEM · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

K L EllisDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Y ZhouDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
L Rodriguez-MurilloDepartments of Pediatrics and Genetics and Genomic Sciences, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J R BeshanskyTufts Medical Center and Tufts University School of Medicine, Boston, MA, USA.
E AinehsazanDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
H P SelkerTufts Medical Center and Tufts University School of Medicine, Boston, MA, USA.
G S HugginsMolecular Cardiology Research Institute Center for Translational Genomics, Tufts Medical Center, Boston, MA, USA.
L A CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
I PeterDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn School of Medicine at Mount Sinai · USBoston University · USTufts Medical Center · USGovernment of Western Australia Department of Health · AURegis College · US

Funding

Early EMS and ED Use of GIK for ACS: The IMMEDIATE TrialU01HL077821 · NHLBI · TUFTS MEDICAL CENTER · PI SELKER, HARRY P · 2004 to 2006
$21.8M
Data Coordinating Center for IMMEDIATE TrialU01HL077826 · NHLBI · TUFTS MEDICAL CENTER · PI D'AGOSTINO, RALPH B · 2004 to 2006
$3.4M
Genetic Markers of GIK Effect in Acute Coronary Syndrome in the IMMEDIATE TrialR01HL090997 · NHLBI · TUFTS MEDICAL CENTER · PI PETER, INGA · 2007 to 2012
$1.5M
LV Function Assessment Core Lab for IMMEDIATE TrialU01HL077823 · NHLBI · TUFTS MEDICAL CENTER · PI UDELSON, JAMES E · 2004 to 2006
$206k
NHLBI NIH HHS R01 HL090997NHLBI NIH HHS U01 HL077821NHLBI NIH HHS U01 HL077823NHLBI NIH HHS U01 HL077826
6 · The paper itself

Abstract

Glucose-insulin-potassium (GIK) therapy may promote a shift from oxygen-wasteful free fatty acid (FFA) metabolism to glycolysis, potentially reducing myocardial damage during ischemia. Genetic variation associated with FFA response to GIK was investigated in an IMMEDIATE (Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency care) sub-study (n=117). In patients with confirmed acute coronary syndromes, associations between 132 634 variants and 12-h circulating FFA response were assessed. Between initial and 6-h measurements, three LINGO2 variants were associated with increased levels of total FFA (P-value for 2 degree of freedom test, P

Indexed as

Pharmacogenomic VariantsPolymorphism, Single NucleotideAcute Coronary SyndromeAgedBiomarkersCardioplegic SolutionsDual-Specificity PhosphatasesFatty Acid-Binding ProteinsFatty Acids, NonesterifiedFemaleGenotypeGlucoseGlycolysisHumansInsulinMaleBiomarkersCardioplegic SolutionsDual-Specificity PhosphatasesDUSP26 protein, humanFABP12 protein, humanFatty Acid-Binding ProteinsFatty Acids, NonesterifiedGlucoseglucose-insulin-potassium cardioplegic solutionInsulinMitogen-Activated Protein Kinase Phosphatasesmyo-inositol-1 (or 4)-monophosphatasePhosphoric Monoester HydrolasesPotassium

Identifiers

PMID26644202
OpenAlexW2190151112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.