ArticleScientific reports2015
A STRIPAK component Strip regulates neuronal morphogenesis by affecting microtubule stability.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Distinct STRIPAK subunits drive conserved and subunit-specific signaling programs inbioRxiv : the preprint server for biology · 2026Article
- Future Directions for Studying the Potential of Mammalian Dscam in Autism Spectrum Disorder and Alzheimer's Disease: Insights from Dose Sensitivity.Molecular neurobiology · 2025Review
- Article
- STRIPAK regulation of katanin microtubule severing in the Caenorhabditis elegans embryo.Genetics · 2022Article
- Article
- The STRIPAK component SipC is involved in morphology and cell-fate determination in the nematode-trapping fungus Duddingtonia flagrans.Genetics · 2022Article
- Pack a STRIPAK with hubs inside a hub.Nature structural & molecular biology · 2021Article
- Characterization ofFrontiers in genetics · 2021Article
- STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity.The Journal of cell biology · 2020Article
- The STRIPAK Complex Regulates Response to Chemotherapy Through p21 and p27.Frontiers in cell and developmental biology · 2020Article
- Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons.The Journal of biological chemistry · 2018Article
- SG2NA is a regulator of endoplasmic reticulum (ER) homeostasis as its depletion leads to ER stress.Cell stress & chaperones · 2017Article
- A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation.The Journal of cell biology · 2017Article
- Biallelic TBCD Mutations Cause Early-Onset Neurodegenerative Encephalopathy.American journal of human genetics · 2016Article
- The Strip-Hippo Pathway Regulates Synaptic Terminal Formation by Modulating Actin Organization at the Drosophila Neuromuscular Synapses.Cell reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During neural development, regulation of microtubule stability is essential for proper morphogenesis of neurons. Recently, the striatin-interacting phosphatase and kinase (STRIPAK) complex was revealed to be involved in diverse cellular processes. However, there is little evidence that STRIPAK components regulate microtubule dynamics, especially in vivo. Here, we show that one of the core STRIPAK components, Strip, is required for microtubule organization during neuronal morphogenesis. Knockdown of Strip causes a decrease in the level of acetylated α-tubulin in Drosophila S2 cells, suggesting that Strip influences the stability of microtubules. We also found that Strip physically and genetically interacts with tubulin folding cofactor D (TBCD), an essential regulator of α- and β-tubulin heterodimers. Furthermore, we demonstrate the genetic interaction between strip and Down syndrome cell adhesion molecule (Dscam), a cell surface molecule that is known to work with TBCD. Thus, we propose that Strip regulates neuronal morphogenesis by affecting microtubule stability.
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