Evidence map›Paper›PMID 26644115›Full record

Trial reportInternational journal of geriatric psychiatry2016

Does targeted cognitive training reduce educational disparities in cognitive function among cognitively normal older adults?

Daniel O Clark, Huiping Xu, Frederick W Unverzagt, Hugh Hendrie

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in International journal of geriatric psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Feasibility of lifestyle interventions for cognition in adults with low education.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Trial
  4. Trial
  5. Dynamic Useful Field of View Training to Enhance Older Adults' Cognitive and Motor Function: A Pilot Study.Journal of cognitive enhancement : towards the integration of theory and practice · 2021
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Speed of processing training results in lower risk of dementia.Alzheimer's & dementia (New York, N. Y.) · 2017
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Daniel O ClarkIndiana University Center for Aging Research, Indianapolis, IN, USA.
Huiping XuDepartment of Biostatistics, Richard M. Fairbanks School of Public Health and School of Medicine, Indiana University, Indianapolis, IN, USA.
Frederick W UnverzagtIndiana University Center for Aging Research, Indianapolis, IN, USA.
Hugh HendrieRegenstrief Institute, Inc., Indianapolis, IN, USA.
Regenstrief Institute · USIndiana University IndianapolisIndiana University – Purdue University Indianapolis · US

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
MAINTENANCE AND ENHANCEMENT OF COGNITIVE ADLSU01NR004508 · NINR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI UNVERZAGT, FREDERICK W. · 1996 to 2010
$2.8M
Cognitive and Aerobic Resilience for the BrainR01AG045157 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI UNVERZAGT, FREDERICK W. · 2014 to 2018
$2.6M
RCT of Video-Conference & In-Person Weight Loss Services for Adult CHC PatientsR01DK092377 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI CLARK, DANIEL O · 2012 to 2015
$1.9M
NIA NIH HHS P30 AG010133NIA NIH HHS R01 AG045157NIDDK NIH HHS R01 DK092377NINR NIH HHS U01 NR004508
6 · The paper itself

Abstract

objectiveThe aim of this study was to investigate educational differences in treatment responses to memory, reasoning, and speed of processing cognitive training relative to no-contact control.

methodsSecondary analyses of the Advanced Cognitive Training for Independent and Vital Elderly trial were conducted. Two thousand eight hundred older adults were randomized to memory, reasoning, or speed of processing training or no-contact control. A repeated-measures mixed-effects model was used to investigate immediate post-training and 1-year outcomes with sensitivity analyses out to 10 years. Outcomes were as follows: (1) memory composite of Hopkins Verbal Learning Test, Rey Auditory Verbal Learning Test, and Rivermead Behavioral Memory Test; (2) reasoning composite of letter series, letter sets, and word series; and (3) speed of processing measured using three trials of useful field of view and the digit symbol substitution test.

resultsThe effects of reasoning and memory training did not differ by educational attainment. The effect of speed of processing training did. Those with fewer than 12 years of education experienced a 50% greater effect on the useful field of view test compared with those with 16 or more years of education. The training advantage for those with fewer than 12 years of education was maintained to 3 years post-training.

conclusionOlder adults with less than a secondary education are at elevated risk of dementia, including Alzheimer's disease. The analyses here indicate that speed of processing training is effective in older adults with low educational attainment.

Indexed as

Educational StatusHealth Status DisparitiesLearningMemoryAgedAged, 80 and overCognitionCognitive Behavioral TherapyDementiaFemaleHumansMalecognitioncognitive trainingeducationolder adults

Identifiers

PMID26644115
PMCPMC5300706
OpenAlexW2189906079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.