Evidence map›Paper›PMID 26644017›Full record

ArticleInternational journal of clinical pharmacy2016

Chronotherapy in practice: the perspective of the community pharmacist.

Gagandeep Kaur, Yuh-Lin Gan, Craig L Phillips, Keith Wong, Bandana Saini

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of clinical pharmacy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Mapping genes for drug chronotherapy.Drug discovery today · 2018
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Gagandeep KaurFaculty of Pharmacy, University of Sydney, Room S114, Pharmacy and Bank Building A15, Science Road, Camperdown, NSW, 2006, Australia. gaga8947@uni.sydney.edu.au.
Yuh-Lin GanFaculty of Pharmacy, University of Sydney, Room S114, Pharmacy and Bank Building A15, Science Road, Camperdown, NSW, 2006, Australia.
Craig L PhillipsWoolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia.
Keith WongWoolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia.
Bandana SainiFaculty of Pharmacy, University of Sydney, Room S114, Pharmacy and Bank Building A15, Science Road, Camperdown, NSW, 2006, Australia.
University of Sydney · AURoyal North Shore Hospital · AUWoolcock Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOptimising the time of drug administration in alignment with circadian rhythms to enhance the clinical effect or minimise/avoid adverse effects is referred to as chronotherapy. Pharmacists have a key role in providing medicine related information, including counselling about the optimal time for medication administration. Where applicable, the principles of chronotherapy should underlie this aspect of medication counselling. Despite significant developments in the science of chronotherapy for specific pharmacological treatments, the perspective of pharmacists about their understanding and application of these principles in practice has not been explored.

objectiveTo explore community pharmacist's viewpoints about and experience with the application of chronotherapy principles in practice.

settingCommunity pharmacies within metropolitan Sydney in New South Wales, Australia.

methodsSemi-structured, face to face interviews with a convenience sample of community pharmacists were conducted. All interviews were audio-recorded, transcribed verbatim and thematically analyzed using a 'grounded theory' approach, given the novelty of this area. Main outcome measure Community pharmacists' awareness, current practice and future practice support requirements about the principles of chronotherapy.

resultsTwenty-five semi-structured interviews were conducted. Most participants reported encountering cases where clinical decision making about suggesting appropriate times of drug administration to patients was needed. Their approach was mainly pragmatic rather than based on theoretical principles of circadian variation in drug disposition or on current or emerging evidence; thus there was an evidence practice chasm in some cases. However, most participants believed they have an important role to play in counselling patients about optimal administration times and were willing to enact such roles or acquire skills/competence in this area.

conclusionCommunity pharmacists contribute to the safe and effective use of medications in providing the patients with information on optimal timing of drug administration during counselling. Further education, practical training and access to information may help pharmacists in translating principles of chronotherapy into the practice.

Indexed as

Attitude of Health PersonnelCommunity Pharmacy ServicesDrug ChronotherapyHealth Knowledge, Attitudes, PracticePerceptionClinical CompetenceCounselingFemaleGrounded TheoryHumansInterviews as TopicMaleNew South WalesPharmacistsProfessional-Patient RelationsAustraliaChronotherapyCircadian rhythmsCommunity pharmacistTiming of drug administration

Identifiers

PMID26644017
OpenAlexW2276505423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.