Evidence map›Paper›PMID 26643996›Full record

ArticleInternational journal of geriatric psychiatry2016

Anosognosia increases caregiver burden in mild cognitive impairment.

Mary Kelleher, Magdalena I Tolea, James E Galvin

Open access · greenAbstract read
In one paragraph

Article in International journal of geriatric psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 55 citations in OpenAlex.

  1. Theory of Mind Deficits and Awareness in Alzheimer's Disease.Dementia and geriatric cognitive disorders · 2026
    Article
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  3. Contextualizing Caregiver Burden in Mild Cognitive Impairment: A Dyadic Perspective.International journal of environmental research and public health · 2025
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  11. Predictors of caregiver burden in patients with neurologic Wilson disease.The Journal of international medical research · 2020
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  19. Cross domain self-monitoring in anosognosia for memory loss in Alzheimer's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mary KelleherCenter for Cognitive Neurology, NYU Langone Medical Center, New York, NY, USA.
Magdalena I ToleaCenter for Cognitive Neurology, NYU Langone Medical Center, New York, NY, USA.
James E GalvinCenter for Cognitive Neurology, NYU Langone Medical Center, New York, NY, USA.
NYU Langone Health · US

Funding

Multicultural Community Dementia Screening.R01AG040211 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GALVIN, JAMES E · 2011 to 2018
$3.2M
NIA NIH HHS R01 AG040211
6 · The paper itself

Abstract

objectiveOur aim is to determine the clinical correlates of impaired insight in patients with mild cognitive impairment (MCI) by examining its impact on cognition, functional status, neuropsychiatric symptoms, and caregiver burden.

methodsThe study involved 75 patients with MCI and their caregivers. Patients and caregivers underwent a comprehensive evaluation including the Clinical Dementia Rating, memory tests, and the Functional Assessment Questionnaire. Behavioral symptoms were assessed by the Neuropsychiatric Inventory, caregiver burden by the Zarit Burden Inventory, and insight by comparing self-report on the AD8 dementia screening tool to informant collateral. Patients were asked about their perceptions of their memory, and answers were compared with informants' responses. Patient mood was assessed with the Hospital Anxiety Depression Scale.

resultsThere was a significant difference in AD8 scores among patients who retained versus lacked insight. Zarit Burden Inventory scores showed a significant rise as patient insight declined; the burden appeared greater on spouse versus non-spouse caregivers. Patients with poor insight had significantly worse ratings in Clinical Dementia Rating domains of personal care and judgment, while patients who retained insight had significantly higher depression and anxiety. Insight impairment was associated with worse caregiver mood.

conclusionsDecreased patient awareness for cognitive problems was significantly associated with higher caregiver burden, independent of neuropsychiatric symptoms, functional abilities, and cognition. Personal care, judgment, and problem-solving skills could contribute to caregiver burden. Increased awareness seemed a source of patient depression and anxiety. The research highlights the need to focus on the needs of MCI caregivers and to incorporate psychosocial assessments of caregiver-patient dyads into office visits.

Indexed as

AgnosiaAwarenessAdaptation, PsychologicalAgedAged, 80 and overCaregiversCognitive DysfunctionCost of IllnessFemaleHumansMaleMiddle AgedProblem SolvingPsychiatric Status Rating ScalesRegression AnalysisStress, Psychologicalanosognosiacaregiver burdendepressionmild cognitive impairmentneurocognitive disorderspatient insight

Identifiers

PMID26643996
PMCPMC8483618
OpenAlexW2189703469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.