ArticleDiagnostic pathology2015
Differential diagnostic value of CD5 and CD117 expression in thoracic tumors: a large scale study of 1465 non-small cell lung cancer cases.
Article in Diagnostic pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Proceedings of the 2026 North American Society of Head and Neck Pathology Companion Meeting, San Antonio, TX, March 22, 2026: It's a Trap! Pitfalls in Thyroid Pathology: Mets or Not Mets?Head and neck pathology · 2026Review
- Collision tumor of poorly differentiated thyroid carcinoma and intrathyroid thymic carcinoma arising in association with a branchial cleft-like cyst: a case report.Frontiers in oncology · 2026Article
- Head and neck squamous cell carcinomas of unknown primary: Can ancillary studies help identify more primary tumor sites?Experimental and molecular pathology · 2024Article
- CK5/6-positive, P63-positive lymphoepithelioma-like hepatocellular carcinoma: A case report and literature review.World journal of clinical cases · 2023Article
- Modified subcostal arch xiphoid thoracoscopic expanded thymectomy for thymic carcinoma: a case report and review of literature.Journal of cardiothoracic surgery · 2022Review
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- CD70 in Thymic Squamous Cell Carcinoma: Potential Diagnostic Markers and Immunotherapeutic Targets.Frontiers in oncology · 2021Article
- Poorly-differentiated and undifferentiated sarcomas of the mediastinum: a bag of tricks.Mediastinum (Hong Kong, China) · 2021Review
- Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples.International journal of molecular sciences · 2020Article
- An Algorithmic Immunohistochemical Approach to Define Tumor Type and Assign Site of Origin.Advances in anatomic pathology · 2020Review
- Atypical carcinoid: A rare finding of a man with mediastinal mass: A case report.Molecular and clinical oncology · 2020Article
- Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2019Article
- An overview on the differential diagnostics of tumors of the anterior-superior mediastinum: the pathologist's perspective.Mediastinum (Hong Kong, China) · 2019Review
- Resected thymic large cell neuroendocrine carcinoma: report of a case.Surgical case reports · 2018Article
- Expression of HMB45, MelanA and SOX10 is rare in non-small cell lung cancer.Diagnostic pathology · 2018Article
- Classification of pulmonary neuroendocrine tumors: new insights.Translational lung cancer research · 2017Review
- Primary atypical carcinoid tumor of the mediastinum: a very rare finding.Journal of thoracic disease · 2017Article
- Middle mediastinal thymic carcinoma with cystic findings in radiologic images: a case report.Surgical case reports · 2016Article
- [Thymic carcinomas].Der Pathologe · 2016Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThoracic pathologists are frequently faced with tissue specimens from intrathoracic/mediastinal tumors. Specifically the differentiation between thymic and pulmonary squamous cell carcinomas (SqCC) can be challenging. In order to clarify the differential diagnostic value of CD5 and CD117 in this setting, we performed a large scale expression study of both markers in 1465 non-small cell lung cancer (NSCLC) cases.
methodsTissue microarrays of formalin-fixed paraffin-embedded resection specimens of 1465 NSCLC were stained with antibodies against CD117 and CD5. Positivity of both markers was correlated with clinicopathological variables.
resultsCD117 was positive in 145 out of 1457 evaluable cases (9.9 %) and CD5 was positive in 133 out of 1427 evaluable cases (9.3 %). 28 cases (1.9 %) showed coexpression of CD117 and CD5. Among the 145 cases that were positive for CD117, 97 (66.8 %) were adenocarcinomas (ADC), 34 (23.4 %) were SqCC, 5 (3.4 %) were adenosquamous carcinomas (ADSqCC), 8 (5.5 %) were large cell carcinomas (LC), and one (0.6 %) was a pleomorphic carcinoma (PC). In the CD5 positive group consisting of 133 cases, 123 (92.4 %) were ADC, 0 (0 %) were SqCC, 4 (3.0 %) were ADSqCC, 3 (2.2 %) LC and 3 (2.2 %) were PC. None of the 586 SqCC showed expression of CD5. No association of CD117- or CD5 positivity to patients' age, pathological stages or to T-, N-, or M- categories was observed.
conclusionsA substantial subset of NSCLC exhibit positivity of CD117 and CD5. Since CD5 expression was not observed in pulmonary SqCC, but is expressed in the majority of thymic squamous cell carcinomas, the application of this immunomarker is a valuable tool in the differential diagnosis of thoracic neoplasms.
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