ReviewImmunology2016
The emerging roles of the STING adaptor protein in immunity and diseases.
Review in Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Unravelling the impact of linear energy transfer on micronuclei induction from proton and photon irradiation.Scientific reports · 2025Article
- Harnessing DNA polymerase beta defect enhances synthetic lethality and treatment response in gastric cancer cells: implication for immunotherapy.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2025Review
- Functional roles and cancer variants of the bifunctional glycosylase NEIL2.Environmental and molecular mutagenesis · 2024Review
- Review
- Fish female-biased gene cyp19a1a leads to female antiviral response attenuation between sexes by autophagic degradation of MITA.PLoS pathogens · 2022Article
- Defective DNA polymerase beta invoke a cytosolic DNA mediated inflammatory response.Frontiers in immunology · 2022Article
- Atrial Natriuretic Peptide Attenuates Colitis via Inhibition of the cGAS-STING Pathway in Colonic Epithelial Cells.International journal of biological sciences · 2022Article
- Regulation of cGAS-STING Pathway - Implications for Systemic Lupus Erythematosus.Rheumatology and immunology research · 2021Review
- Chicken DDX1 Acts as an RNA Sensor to Mediate IFN-β Signaling Pathway Activation in Antiviral Innate Immunity.Frontiers in immunology · 2021Article
- STING controls intestinal homeostasis through promoting antimicrobial peptide expression in epithelial cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- STING-mediated intestinal barrier dysfunction contributes to lethal sepsis.EBioMedicine · 2019Article
- The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.PLoS pathogens · 2017Article
- Decreased expression of STING predicts poor prognosis in patients with gastric cancer.Scientific reports · 2017Article
- The emerging roles of the DDX41 protein in immunity and diseases.Protein & cell · 2017Review
- Stimulator of Interferon Genes Deficiency in Acute Exacerbation of Idiopathic Pulmonary Fibrosis.Frontiers in immunology · 2017Article
- SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing.PLoS pathogens · 2017Article
- Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA that gains access to the cytoplasm generally serves as a danger signal for the hosts. An emerging paradigm for responding to cytosolic DNAs centres on the endoplasmic reticulum-resident protein stimulator of interferon genes (STING, also known as MITA, ERIS or MPYS), the hub adaptor of the recently identified DNA sensors. Dynamic regulations of STING action are critical for shaping innate immune responses against microbial infections, as well as for preventing autoimmune diseases. STING is also indispensable for the detection of immunogenic tumours. A deeper understanding of STING modulations could be instrumental for developing novel immunotherapeutic strategies against infectious, autoimmune and cancerous diseases. In this review, we summarize the latest advances on the role of STING in the DNA-triggered immune reactions, and underscore the critical issues that remain to be resolved in future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.