ArticleEndoscopic ultrasound
Endoscopic ultrasound-guided radiofrequency ablation of the pancreas: An experimental study with pathological correlation.
Article in Endoscopic ultrasound. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Review
- A Review on Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of Pancreatic Lesions.Diagnostics (Basel, Switzerland) · 2023Review
- Cystic pancreatic lesions, the endless dilemma.World journal of gastroenterology · 2021Article
- EUS-guided pancreatic radiofrequency ablation: preclinical comparison of two currently available devices in a pig model.Endoscopy international open · 2019Article
- EUS-guided radiofrequency ablation of small pancreatic adenocarcinoma: a new therapeutic option for patients unfit for surgery.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2019Article
- Future Perspectives on Endoscopic Ultrasonography-Guided Therapy for Pancreatic Neoplasm.Clinical endoscopy · 2018Article
- EUS-guided solid pancreatic tumor ablation.Endoscopic ultrasound · 2017Article
- Endoscopic Ultrasound-guided Pancreatic Pseudocyst Drainage with Lumen-apposing Metal Stents or Plastic Double-pigtail Stents: A Multifactorial Analysis.Journal of translational internal medicine · 2017Article
- Endoscopic ultrasound-guided radiofrequency ablation in gastroenterology: New horizons in search.World journal of gastroenterology · 2017Review
- Endoscopic Radiofrequency Ablation of the Pancreas.Digestive diseases and sciences · 2017Review
- EUS-guided radiofrequency ablation: Where we are?Endoscopic ultrasoundArticle
- Biliary Stenting for Malignant Biliary Obstruction Secondary to Pancreatic Cancer.Current health sciences journalArticle
- Systematic review of endoscopy ultrasound-guided thermal ablation treatment for pancreatic cancer.Endoscopic ultrasoundReview
- Endoscopic ultrasound-guided ablation of pancreatic cystic neoplasms: ready for prime time?Annals of gastroenterologyReview
- Radiofrequency ablation for pancreatobiliary disease: an updated review.Annals of gastroenterologyReview
- In Vivo Experimental Study of an Endoscopic Ultrasound Multifunctional Radiofrequency Ablation Probe.Current health sciences journalArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe treatment of pancreatic cancer represents a major objective in clinical research, as it still remains the fourth leading cause of cancer deaths among men and women, with approximately 6% of all cancer-related deaths. MATERIALS AND
methodsWe studied the assessment of an endoscopic ultrasound (EUS)-guided radiofrequency ablation (RFA) probe through a 19G needle in order to achieve a desirable necrosis area in the pancreas. Radiofrequency ablation of the head of the pancreas was performed on 10 Yorkshire pigs with a weight between 25 kg and 35 kg and a length of 40-70 cm. Using an EUS-guided RFA experimental probe, we ablated an area of 2-3 cm width. The biological samples were harvested after 3 days and 5 days and necropsy was performed 1 week after the procedure.
resultsAll pigs showed no significant change regarding their behavior and no signs of complication was encountered. Blood analysis revealed increased values of amylase, alkaline phosphatase, and gamma-glutamyl transpeptidase on the 3rd day but a decrease on the 5th day. After necropsy and isolation of the pancreas, the ablated area was easily found, describing a solid necrosis. The pathological examination revealed a coagulative necrosis area with minimal invasion and inflammatory tissue at about 2 cm surrounding the lesion.
conclusionEUS-RFA is a feasible technique and might represent a promising therapy for the future treatment of pancreatic cancer. However, further studies are necessary to investigate EUS-guided RFA as an option for palliation in pancreatic cancer until it can be successfully used in human patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.