Evidence map›Paper›PMID 26643532›Full record

ArticleThe American journal of tropical medicine and hygiene2016

Distribution of Enteroinvasive and Enterotoxigenic Escherichia coli Across Space and Time in Northwestern Ecuador.

Darlene Bhavnani, Rosa de los Ángeles Bayas, Velma K Lopez, Lixin Zhang, Gabriel Trueba, Betsy Foxman, Carl Marrs, William Cevallos, Joseph N S Eisenberg

Abstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Indole signaling inGut microbes · 2025
    Review
  2. Distribution of Escherichia coli Pathotypes along an Urban-Rural Gradient in Ecuador.The American journal of tropical medicine and hygiene · 2023
    Article
  3. Population genomics of diarrheagenic Escherichia coli uncovers high connectivity between urban and rural communities in Ecuador.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Darlene BhavnaniDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador dbhavnani@clintonhealthaccess.org.
Rosa de los Ángeles BayasDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
Velma K LopezDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
Lixin ZhangDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
Gabriel TruebaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
Betsy FoxmanDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
Carl MarrsDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
William CevallosDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
Joseph N S EisenbergDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.

Funding

Environment Change and Diarrheal Disease: A Natural ExperimentR01AI050038 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EISENBERG, JOSEPH N. S. · 2003 to 2012
$6.1M
Interdisciplinary Training Program in Infectious DiseasesT32AI049816 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FOXMAN, BETSY · 2002 to 2011
$1.5M
NIAID NIH HHS R01 AI050038NIAID NIH HHS R01-AI050038NIAID NIH HHS T32 AI049816NIAID NIH HHS T32AI049816
6 · The paper itself

Abstract

Although Escherichia coli infections are common throughout the developing world, their prevalence patterns in space and over time are not well characterized. We used serial case control data collected from 16 communities in northwestern Ecuador between 2004 and 2010, to examine the prevalence of enteroinvasive E. coli (EIEC) and enterotoxigenic E. coli (ETEC). At its peak, the regional prevalence of EIEC was 8.3 infections/100 persons but this decreased to 1 infection/1,000 persons. The regional prevalence of ETEC ranged from 8 infections/1,000 persons to 3.7 infections/100 persons. The prevalence pattern of EIEC resembled that of a large epidemic whereas the prevalence of ETEC was more stable over time. Here, we provide community-based evidence for temporal shifts in the dominant E. coli pathotype from EIEC to ETEC over a multi-year time period. Furthermore, genotype analysis suggests that a given strain of EIEC and ETEC can persist in this region for long periods, up to 24 and 55 months, respectively.

Indexed as

Enterotoxigenic Escherichia coliCase-Control StudiesEcuadorEscherichia coli InfectionsGenotypeHumansPrevalenceTime Factors

Identifiers

PMID26643532
PMCPMC4751959

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.