Evidence map›Paper›PMID 26643385›Full record

ArticleSkeletal radiology2016

In-vivo T2-relaxation times of asymptomatic cervical intervertebral discs.

Sean J Driscoll, Weiye Zhong, Martin Torriani, Haiqing Mao, Kirkham B Wood, Thomas D Cha, Guoan Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Skeletal radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sean J DriscollBioengineering Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital/Harvard Medical School, 55 Fruit Street, GRJ 1215, Boston, MA, 02114, USA.
Weiye ZhongBioengineering Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital/Harvard Medical School, 55 Fruit Street, GRJ 1215, Boston, MA, 02114, USA.
Martin TorrianiMusculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, 55 Fruit Street, YAW 6E, Boston, MA, 02114, USA.
Haiqing MaoBioengineering Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital/Harvard Medical School, 55 Fruit Street, GRJ 1215, Boston, MA, 02114, USA.
Kirkham B WoodSpine Service, Department of Orthopaedic Surgery, Massachusetts General Hospital/Harvard Medical School, 55 Fruit Street, YAW 3A, Boston, MA, 02114, USA.
Thomas D ChaSpine Service, Department of Orthopaedic Surgery, Massachusetts General Hospital/Harvard Medical School, 55 Fruit Street, YAW 3A, Boston, MA, 02114, USA.
Guoan LiBioengineering Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital/Harvard Medical School, 55 Fruit Street, GRJ 1215, Boston, MA, 02114, USA. gli1@mgh.harvard.edu.

Funding

In-vivo Lumbar Disc DeformationR21AR057989 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI LI, GUOAN · 2010 to 2011
$432k
NIAMS NIH HHS R21 AR057989NIAMS NIH HHS R21AR057989
6 · The paper itself

Abstract

Limited research exists on T2-mapping techniques for cervical intervertebral discs and its potential clinical utility. The objective of this research was to investigate the in-vivo T2-relaxation times of cervical discs, including C2-C3 through C7-T1. Ten asymptomatic subjects were imaged using a 3.0 T MR scanner and a sagittal multi-slice multi-echo sequence. Using the mid-sagittal image, intervertebral discs were divided into five regions-of-interest (ROIs), centered along the mid-line of the disc. Average T2 relaxation time values were calculated for each ROI using a mono-exponential fit. Differences in T2 values between disc levels and across ROIs of the same disc were examined. For a given ROI, the results showed a trend of increasing relaxation times moving down the spinal column, particularly in the middle regions (ROIs 2, 3 and 4). The C6-C7 and C7-T1 discs had significantly greater T2 values compared to superior discs (discs between C2 and C6). The results also showed spatial homogeneity of T2 values in the C3-C4, C4-C5, and C5-C6 discs, while C2-C3, C6-C7, and C7-T1 showed significant differences between ROIs. The findings indicate there may be inherent differences in T2-relaxation time properties between different cervical discs. Clinical evaluations utilizing T2-mapping techniques in the cervical spine may need to be level-dependent.

Indexed as

AdultCervical VertebraeFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedIntervertebral DiscMagnetic Resonance ImagingMaleReference ValuesReproducibility of ResultsSensitivity and SpecificitySymptom AssessmentCervical spineIntervertebral discIn vivoMagnetic resonance imagingT2 mapping

Identifiers

PMID26643385
PMCPMC4718756

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.