Evidence map›Paper›PMID 26643312›Full record

SynthesisEndocrine2016

Sexual dysfunction in women with cancer: a systematic review with meta-analysis of studies using the Female Sexual Function Index.

Maria Ida Maiorino, Paolo Chiodini, Giuseppe Bellastella, Dario Giugliano, Katherine Esposito

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Endocrine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03257670 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Prospective Randomized Trial Comparing Treatment of Dyspareunia With Fractional CO2 Laser Therapy Versus 4% Topical Lidocaine Gel in the Setting of Breast Cancer Survivors.

TypeinterventionalSponsorUniversity of CincinnatiRan2018 to 2022Enrolled70ConditionsDyspareuniaArms4% Topical Lidocaine Gel, CO2RE fractional laser therapy
NCT06458764 unknown statusnot on this mapstarted 2023, after this paper: background citation

SEXCHECK - Sexual Dysfunction Check-up in Premenopausal Breast Cancer Survivors Taking Endocrine Therapy: A Cross-Sectional Study

Typeobservational_patient_registrySponsorCandiolo Cancer Institute - IRCCSRan2023 to 2025Enrolled150ConditionsBreast Cancer Female, Sexual Dysfunction, Premenopausal Breast CancerArmsQuestionnaire
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  6. Sexual Dysfunction in Women with Cancer: A Systematic Review of Longitudinal Studies.International journal of environmental research and public health · 2022
    Pooled it
  7. Pooled it
  8. Incidence and severity of sexual dysfunction among women with breast cancer: a meta-analysis based on female sexual function index.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Hormone therapy use and cancer survivorship.Menopause (New York, N.Y.) · 2026
    Article
  13. Article
  14. Article
  15. Sexual health in older adults with hematologic malignancies - a sub-analysis of a Danish cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  16. Sexual dysfunction and its impact on quality of life among female haematological cancer patients: a cross-sectional study in Malaysia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Ida MaiorinoEndocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Diseases and Aging, Second University of Naples, Piazza L. Miraglia n° 2, 80138, Naples, Italy. mariaida.maiorino@unina2.it.
Paolo ChiodiniMedical Statistics Unit, Second University of Naples, via L. Armanni n° 5, 80138, Naples, Italy.
Giuseppe BellastellaEndocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Diseases and Aging, Second University of Naples, Piazza L. Miraglia n° 2, 80138, Naples, Italy.
Dario GiuglianoEndocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Diseases and Aging, Second University of Naples, Piazza L. Miraglia n° 2, 80138, Naples, Italy.
Katherine EspositoDepartment of Clinical and Experimental Medicine, Second University of Naples, via Pansini n° 5, 80131, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer may impair sexual function in women. We provide an overview of studies that address Female Sexual Dysfunction (FSD) in women with cancer with a meta-analysis of observational studies that used a validated diagnostic tool. Searches included MEDLINE, Scopus, and Google Scholar for studies published from January 2000 to 31 December 2014. Every included study had to involve at least 30 cancer patients, to investigate FSD based on the Female Sexual Function Index (FSFI), and to have been published in peer-review journals. Duplicate independent data extraction and quality assessment were performed. Data were pooled using a random effects model if statistical heterogeneity was present. The main outcomes were FSFI total score and FSD prevalence. FSFI is a 19-item self-report instrument for assessing key dimensions of female sexual function. A value less than 26.55 is consistent with FSD. Thirty-five studies met the inclusion criteria. Among these, 27 reported FSFI scores, and 16 FSD prevalence. Most studies (56 %) had low to moderate quality. The mean value of FSFI was lower than 20 at all cancer sites: 16.25 (pooled random effect, 95 % CI 14.91-17.58, I

Indexed as

ComorbidityFemaleHumansNeoplasmsPrevalenceSexual Dysfunction, PhysiologicalSexual Dysfunctions, PsychologicalCancerFemale Sexual DysfunctionFemale Sexual Function IndexSexual HealthWomen

Identifiers

PMID26643312

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.