Evidence map›Paper›PMID 26643021›Full record

ReviewAnnual review of biomedical engineering2015

Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease.

Nenad Bursac, Mark Juhas, Thomas A Rando

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of biomedical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
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  6. Article
  7. Article
  8. Article
  9. Review
  10. Nanomaterial for Skeletal Muscle Regeneration.Tissue engineering and regenerative medicine · 2022
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nenad BursacDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708; email: nbursac@duke.edu.
Mark JuhasDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708; email: nbursac@duke.edu.
Thomas A RandoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305.
Duke University · USVA Palo Alto Health Care System · US

Funding

Wnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNE BRUNET · 2011 to 2026
$29.3M
Interaction of Subchondral Bone and Articular Cartilage System with Skeletal MuscleUH3TR000505 · NCATS · DUKE UNIVERSITY · PI TRUSKEY, GEORGE A · 2014 to 2016
$3.6M
Notch Signaling and Satellite Cell ActivationR37AG023806 · NIA · STANFORD UNIVERSITY · PI RANDO, THOMAS A. · 2010 to 2019
$2.9M
Circulatory system and integrated muscle tissue for drug and tissue toxicityUH2TR000505 · NCATS · DUKE UNIVERSITY · PI TRUSKEY, GEORGE A · 2012 to 2013
$2.1M
Translational studies of GAA deficiency in bioengineered human muscleR01AR065873 · NIAMS · DUKE UNIVERSITY · PI BURSAC, NENAD, KOEBERL, DWIGHT D · 2013 to 2017
$1.8M
Engineering a Functional Skeletal MuscleR01AR055226 · NIAMS · DUKE UNIVERSITY · PI BURSAC, NENAD · 2008 to 2012
$1.6M
The Function and Regulation of Pax3 in Muscle Stem CellsR01AR062185 · NIAMS · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI RANDO, THOMAS A. · 2011 to 2015
$1.5M
Notch Signaling and Satellite Cell ActivationR01AG023806 · NIA · STANFORD UNIVERSITY · PI RANDO, THOMAS A. · 2005 to 2009
$1.2M
Muscle Stem Cell Therapy for Volumetric Muscle LossI01RX001222 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI HUANG, NGAN F. · 2014 to 2023
–
The Effect of Exercise on the Efficacy of Muscle Regenerative TherapyI21RX001413 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI RANDO, THOMAS A. · 2014 to 2015
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NCATS NIH HHS UH2 TR000505NCATS NIH HHS UH2TR000505NCATS NIH HHS UH3 TR000505NIAMS NIH HHS AR055226NIAMS NIH HHS AR065873NIAMS NIH HHS R01 AR055226NIAMS NIH HHS R01 AR062185NIAMS NIH HHS R01 AR065873NIA NIH HHS P01 AG036695NIA NIH HHS R01 AG023806NIA NIH HHS R01 AG23806NIA NIH HHS R37 AG023806RRD VA I21 RX001413
6 · The paper itself

Abstract

Although skeletal muscle is one of the most regenerative organs in our body, various genetic defects, alterations in extrinsic signaling, or substantial tissue damage can impair muscle function and the capacity for self-repair. The diversity and complexity of muscle disorders have attracted much interest from both cell biologists and, more recently, bioengineers, leading to concentrated efforts to better understand muscle pathology and develop more efficient therapies. This review describes the biological underpinnings of muscle development, repair, and disease, and discusses recent bioengineering efforts to design and control myomimetic environments, both to study muscle biology and function and to aid in the development of new drug, cell, and gene therapies for muscle disorders. The synergy between engineering-aided biological discovery and biology-inspired engineering solutions will be the path forward for translating laboratory results into clinical practice.

Indexed as

Models, BiologicalAnimalsBiomedical EngineeringBiomimeticsHumansMuscle DevelopmentMuscle, SkeletalMuscular DiseasesRegenerationSatellite Cells, Skeletal Muscledystrophyengineered muscleiPSCsregenerationsatellite cellvolumetric muscle loss

Identifiers

PMID26643021
PMCPMC4858326
OpenAlexW1928840956

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.