ArticleCell research2016
Dicer-independent RNA-directed DNA methylation in Arabidopsis.
Article in Cell research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed.
- Somatic mobility of transposons is explosive and shaped by distinct integration biases in Arabidopsis thaliana.Genome biology · 2026Article
- Epigenetic gene regulation in plants and its potential applications in crop improvement.Nature reviews. Molecular cell biology · 2025Review
- Class-agnostic annotation of small RNAs balances sensitivity and specificity in diverse organisms.Computational and structural biotechnology journal · 2025Article
- Mapping parental DMRs predictive of local and distal methylome remodeling in epigenetic F1 hybrids.Life science alliance · 2024Article
- A Non-Canonical Pathway Induced by Externally Applied Virus-Specific dsRNA in Potato Plants.International journal of molecular sciences · 2023Article
- DNA-dependent RNA polymerases in plants.The Plant cell · 2023Article
- Unravelling Differential DNA Methylation Patterns in Genotype Dependent Manner under Salinity Stress Response in Chickpea.International journal of molecular sciences · 2023Article
- Genomic methylation patterns in pre-meiotic gynoecia of wild-type and RdDM mutants of Arabidopsis.Frontiers in plant science · 2023Article
- Parental mutations influence wild-type offspring via transcriptional adaptation.Science advances · 2022Article
- Roles of RNA silencing in viral and non-viral plant immunity and in the crosstalk between disease resistance systems.Nature reviews. Molecular cell biology · 2022Review
- CRISPR-Cas-mediated transcriptional control and epi-mutagenesis.Plant physiology · 2022Review
- Reinforcement of CHH methylation through RNA-directed DNA methylation ensures sexual reproduction in rice.Plant physiology · 2022Article
- Article
- Retrotransposons: How the continuous evolutionary front shapes plant genomes for response to heat stress.Frontiers in plant science · 2022Review
- You shall not pass! A Chromatin barrier story in plants.Frontiers in plant science · 2022Review
- Pathway conversion enables a double-lock mechanism to maintain DNA methylation and genome stability.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The effect of RNA polymerase V on 24-nt siRNA accumulation depends on DNA methylation contexts and histone modifications in rice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Virus-Mediated Targeted DNA Methylation Illuminates the Dynamics of Methylation in an Endogenous Plant Gene.International journal of molecular sciences · 2021Article
- Roles of DEMETER in regulating DNA methylation in vegetative tissues and pathogen resistance.Journal of integrative plant biology · 2021Article
- Dicer-like proteins influence Arabidopsis root microbiota independent of RNA-directed DNA methylation.Microbiome · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
RNA-directed DNA methylation (RdDM) is an important de novo DNA methylation pathway in plants. Small interfering RNAs (siRNAs) generated by Dicers from RNA polymerase IV (Pol IV) transcripts are thought to guide sequence-specific DNA methylation. To gain insight into the mechanism of RdDM, we performed whole-genome bisulfite sequencing of a collection of Arabidopsis mutants, including plants deficient in Pol IV (nrpd1) or Dicer (dcl1/2/3/4) activity. Unexpectedly, of the RdDM target loci that required Pol IV and/or Pol V, only 16% were fully dependent on Dicer activity. DNA methylation was partly or completely independent of Dicer activity at the remaining Pol IV- and/or Pol V-dependent loci, despite the loss of 24-nt siRNAs. Instead, DNA methylation levels correlated with the accumulation of Pol IV-dependent 25-50 nt RNAs at most loci in Dicer mutant plants. Our results suggest that RdDM in plants is largely guided by a previously unappreciated class of Dicer-independent non-coding RNAs, and that siRNAs are required to maintain DNA methylation at only a subset of loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.