Evidence map›Paper›PMID 26642738›Full record

ArticleCurrent eye research2016

Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina.

Arul K Shanmugam, Barbara A Mysona, Jing Wang, Jing Zhao, Amany Tawfik, A Sanders, Shanu Markand, Eric Zorrilla, Vadivel Ganapathy, Kathryn E Bollinger and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current eye research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Neuroprotective strategies for retinal disease.Progress in retinal and eye research · 2018
    Review
  6. Lens Biology is a Dimension of Neurobiology.Neurochemical research · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Arul K Shanmugama Department of Cellular Biology and Anatomy , Medical College of Georgia, Georgia Regents University , Augusta , GA , USA.
Barbara A Mysonaa Department of Cellular Biology and Anatomy , Medical College of Georgia, Georgia Regents University , Augusta , GA , USA.
Jing Wanga Department of Cellular Biology and Anatomy , Medical College of Georgia, Georgia Regents University , Augusta , GA , USA.
Jing Zhaob James & Jean Culver Vision Discovery Institute , Georgia Regents University , Augusta , GA , USA.
Amany Tawfika Department of Cellular Biology and Anatomy , Medical College of Georgia, Georgia Regents University , Augusta , GA , USA.
A Sandersa Department of Cellular Biology and Anatomy , Medical College of Georgia, Georgia Regents University , Augusta , GA , USA.
Shanu Markanda Department of Cellular Biology and Anatomy , Medical College of Georgia, Georgia Regents University , Augusta , GA , USA.
Eric Zorrillad Harold L. Dorris Neurological Research Institute , The Scripps Research Institute , La Jolla , CA , USA.
Vadivel Ganapathyb James & Jean Culver Vision Discovery Institute , Georgia Regents University , Augusta , GA , USA.
Kathryn E Bollingera Department of Cellular Biology and Anatomy , Medical College of Georgia, Georgia Regents University , Augusta , GA , USA.
Sylvia B Smitha Department of Cellular Biology and Anatomy , Medical College of Georgia, Georgia Regents University , Augusta , GA , USA.
Discovery Institute · USAugusta University · USScripps Research Institute · USTexas Tech University · US

Funding

Diabetic retinopathy: sigma receptor 1 (??R1) as a novel therapeutic target.R01EY014560 · NEI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI SMITH, SYLVIA B. · 2004 to 2013
$2.7M
Molecular Mechanisms of Sigma Receptor 1-Mediated NeuroprotectionK08EY021758 · NEI · AUGUSTA UNIVERSITY · PI BOLLINGER, KATHRYN · 2011 to 2015
$1.1M
NEI NIH HHS K08 EY021758NEI NIH HHS R01 EY014560
6 · The paper itself

Abstract

purposeSigma receptors 1 (σR1) and 2 (σR2) are thought to be two distinct proteins which share the ability to bind multiple ligands, several of which are common to both receptors. Whether σR1 and σR2 share overlapping biological functions is unknown. Recently, progesterone receptor membrane component 1 (PGRMC1) was shown to contain the putative σR2 binding site. PGRMC1 has not been studied in retina. We hypothesize that biological interactions between σR1 and PGRMC1 will be evidenced by compensatory upregulation of PGRMC1 in σR1

methodsImmunofluorescence, RT-PCR, and immunoblotting methods were used to analyze expression of PGRMC1 in wild-type mouse retina. Tissues from σR1

resultsIn the eye, PGRMC1 is expressed in corneal epithelium, lens, ciliary body epithelium, and retina. In retina, PGRMC1 is present in Müller cells and retinal pigment epithelium. This expression pattern is similar, but not identical to σR1. PGRMC1 protein levels in neural retina and eye cup from σR1

conclusionDespite potential biological overlap, deletion of σR1 did not result in a compensatory change in PGRMC1 protein levels in σR1

Indexed as

Gene Expression RegulationAnimalsEpendymoglial CellsImmunoblottingMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutModels, AnimalReceptors, ProgesteroneRetinal Ganglion CellsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerMembrane ProteinsPGRMC1 protein, mouseReceptors, ProgesteroneRNA, MessengerMouseMüller cellsneuroprotectionprogesterone receptor membrane complex 1retinasigma receptorsigma receptor 1sigma receptor 2

Identifiers

PMID26642738
PMCPMC4896862
OpenAlexW2277489948

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.