ArticleIEEE transactions on medical imaging2016
Phase-Contrast Micro-Computed Tomography Measurements of the Intraocular Pressure-Induced Deformation of the Porcine Lamina Cribrosa.
Article in IEEE transactions on medical imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 56 citations in OpenAlex.
- In vivo characterization of the deformation of the human optic nerve head using optical coherence tomography and digital volume correlation.Acta biomaterialia · 2019Trial
- Peripapillary scleral stiffening increases optic nerve head shear deformation in porcine eyes during IOP elevation.Experimental eye research · 2025Article
- LED-based optoacoustic tomography of mice.Journal of biomedical optics · 2025Article
- Morphological Comparison of Astrocytes in the Lamina Cribrosa and Glial Lamina.Investigative ophthalmology & visual science · 2025Article
- Acute ocular hypertension in the living human eye: Model description and initial cellular responses to elevated intraocular pressure.Vision research · 2024Article
- Comparing continuum and direct fiber models of soft tissues. An ocular biomechanics example reveals that continuum models may artificially disrupt the strains at both the tissue and fiber levels.bioRxiv : the preprint server for biology · 2024Article
- Morphological comparison of astrocytes in the lamina cribrosa and glial lamina.bioRxiv : the preprint server for biology · 2024Article
- Quantitative evaluation of biomechanical properties of optic nerve head by using acoustic radiation force optical coherence elastography.Neurophotonics · 2023Article
- A direct fiber approach to model sclera collagen architecture and biomechanics.Experimental eye research · 2023Article
- Three-Dimensional Ultrasound Elastography Detects Age-Related Increase in Anterior Peripapillary Sclera and Optic Nerve Head Compression During IOP Elevation.Investigative ophthalmology & visual science · 2023Article
- Stretch-Induced Uncrimping of Equatorial Sclera Collagen Bundles.Journal of biomechanical engineering · 2023Article
- The Effects of Negative Periocular Pressure on Biomechanics of the Optic Nerve Head and Cornea: A Computational Modeling Study.Translational vision science & technology · 2023Article
- Assessment of the viscoelastic mechanical properties of the porcine optic nerve head using micromechanical testing and finite element modeling.Acta biomaterialia · 2021Article
- Tensile Viscoelastic Properties of the Sclera after Glycosaminoglycan Depletion.Current eye research · 2021Article
- Effect of different preconditioning protocols on the viscoelastic inflation response of the posterior sclera.Acta biomaterialia · 2021Article
- Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements.Materials (Basel, Switzerland) · 2021Article
- So-Called Lamina Cribrosa Defects May Mitigate IOP-Induced Neural Tissue Insult.Investigative ophthalmology & visual science · 2020Article
- IOP-induced regional displacements in the optic nerve head and correlation with peripapillary sclera thickness.Experimental eye research · 2020Article
- The inflation response of the human lamina cribrosa and sclera: Analysis of deformation and interaction.Acta biomaterialia · 2020Article
- Three-dimensional visualization of microvasculature from few-projection data using a novel CT reconstruction algorithm for propagation-based X-ray phase-contrast imaging.Biomedical optics express · 2020Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
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Abstract
The lamina cribrosa (LC) is a complex mesh-like tissue in the posterior eye. Its biomechanical environment is thought to play a major role in glaucoma, the second most common cause of blindness. Due to its small size and relative inaccessibility, high-resolution measurements of LC deformation, important in characterizing LC biomechanics, are challenging. Here we present a novel noninvasive imaging method, which enables measurement of the three-dimensional deformation of the LC caused by acute elevation of intraocular pressure (IOP). Posterior segments of porcine eyes were imaged using synchrotron radiation phase contrast micro-computed tomography (PC μCT) at IOPs between 6 and 37 mmHg. The complex trabecular architecture of the LC was reconstructed with an isotropic spatial resolution of 3.2 μm. Scans acquired at different IOPs were analyzed with digital volume correlation (DVC) to compute full-field deformation within the LC. IOP elevation caused substantial tensile, shearing and compressive devformation within the LC, with maximum tensile strains at 30 mmHg averaging 5.5%, and compressive strains reaching 20%. We conclude that PC μCT provides a novel high-resolution method for imaging the LC, and when combined with DVC, allows for full-field 3D measurement of ex vivo LC biomechanics at high spatial resolution.
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