Evidence map›Paper›PMID 26642314›Full record

SynthesisPloS one2015

Bladder Cancer in HIV-infected Adults: An Emerging Issue? Case-Reports and Systematic Review.

Sylvain Chawki, Guillaume Ploussard, Claire Montlahuc, Jérome Verine, Pierre Mongiat-Artus, François Desgrandchamps, Jean-Michel Molina

Open access · goldAbstract readCase ReportsSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Sylvain ChawkiDepartment of Infectious Diseases, Saint Louis Hospital, Assistance Publique Hôpitaux de Paris, Université de Paris Diderot, Paris 7, Sorbonne Paris Cité, Paris, France.
Guillaume PloussardDepartment of Urology, Saint Louis Hospital, Assistance Publique Hôpitaux de Paris, Université de Paris Diderot, Paris 7, Sorbonne Paris Cité, Paris, France.
Claire MontlahucDepartment of Biostatistic and Medical Information, Saint Louis Hospital, Assistance Publique Hôpitaux de Paris, Université de Paris Diderot, Paris 7, Sorbonne Paris Cité, Paris, France.
Jérome VerineDepartment of Pathology, Saint Louis Hospital, Assistance Publique Hôpitaux de Paris, Université de Paris Diderot, Paris 7, Sorbonne Paris Cité, Paris, France.
Pierre Mongiat-ArtusDepartment of Urology, Saint Louis Hospital, Assistance Publique Hôpitaux de Paris, Université de Paris Diderot, Paris 7, Sorbonne Paris Cité, Paris, France.
François DesgrandchampsDepartment of Urology, Saint Louis Hospital, Assistance Publique Hôpitaux de Paris, Université de Paris Diderot, Paris 7, Sorbonne Paris Cité, Paris, France.
Jean-Michel MolinaDepartment of Infectious Diseases, Saint Louis Hospital, Assistance Publique Hôpitaux de Paris, Université de Paris Diderot, Paris 7, Sorbonne Paris Cité, Paris, France.
Assistance Publique – Hôpitaux de Paris · FRDélégation Paris 7 · FRUniversité Paris Cité · FRSorbonne Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesNon-AIDS-related malignancies now represent a frequent cause of death among HIV-infected patients. Albeit bladder cancer is one of the most common malignancies worldwide, it has been rarely reported among HIV-infected patients. We wished to assess the prevalence and characteristics of bladder cancer in HIV-infected patients.

methodsWe conducted a single center retrospective study from 1998 to 2013 in a university hospital in Paris. Cases of bladder cancer among HIV-infected patients were identified using the electronic records of the hospital database and of the HIV-infected cohort. Patient characteristics and outcomes were retrieved from patients charts. A systematic review of published cases of bladder cancers in patients with HIV-infection was also performed.

resultsDuring the study period we identified 15 HIV-infected patients (0.2% of the cohort) with a bladder cancer. Patients were mostly men (73%) and smokers (67%), with a median age of 56 years at cancer diagnosis. Bladder cancer was diagnosed a median of 14 years after HIV-infection. Most patients were on ART (86%) with median current and nadir CD4 cell counts of 506 and 195 cells/mm3, respectively. Haematuria (73%) was the most frequent presenting symptom and HPV-associated lesions were seen in 6/10 (60%) patients. Histopathology showed transitional cell carcinoma in 80% and a high proportion of tumors with muscle invasion (47%) and high histologic grade (73%). One-year survival rate was 74.6%. The systematic review identified 13 additional cases of urothelial bladder cancers which shared similar features.

conclusionsBladder cancers in HIV-infected patients remain rare but may occur in relatively young patients with a low nadir CD4 cell count, have aggressive pathological features and can be fatal.

Indexed as

HIV-1HIV InfectionsUrinary Bladder NeoplasmsFemaleHematuriaHumansMaleMiddle AgedRetrospective StudiesSmoking

Identifiers

PMID26642314
PMCPMC4671620
OpenAlexW2190890352

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.