Evidence map›Paper›PMID 26642242›Full record

ArticleNature genetics2016

Visualizing spatial population structure with estimated effective migration surfaces.

Desislava Petkova, John Novembre, Matthew Stephens

Abstract read
In one paragraph

Article in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 260 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
260citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

260 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Estimating human mobility in Holocene Western Eurasia with large-scale ancient genomic data.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Pooled it
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  18. Conservation Units for Anadromous Arctic Char (Evolutionary applications · 2026
    Article
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200 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Desislava PetkovaDepartment of Statistics, The University of Chicago, Chicago, Illinois, USA.
John NovembreDepartment of Human Genetics, The University of Chicago, Chicago, Illinois, USA.
Matthew StephensDepartment of Statistics, The University of Chicago, Chicago, Illinois, USA.

Funding

Genome analysis: statistical methods and applicationsR01HG002585 · NHGRI · UNIVERSITY OF WASHINGTON · PI MATTHEW STEPHENS · 2002 to 2026
$8.4M
Tools for Visualization of Geographic Structure in Population Genomic DataU01CA198933 · NCI · UNIVERSITY OF CHICAGO · PI NOVEMBRE, JOHN · 2015 to 2017
$1.2M
Genome analysis: statistical methods and applicationsR56HG002585 · NHGRI · UNIVERSITY OF CHICAGO · PI STEPHENS, MATTHEW · 2023 to 2023
$292k
NCI NIH HHS U01 CA198933NHGRI NIH HHS HG02585NHGRI NIH HHS R01 HG002585NHGRI NIH HHS R56 HG002585
6 · The paper itself

Abstract

Genetic data often exhibit patterns broadly consistent with 'isolation by distance'-a phenomenon where genetic similarity decays with geographic distance. In a heterogeneous habitat, this may occur more quickly in some regions than in others: for example, barriers to gene flow can accelerate differentiation between neighboring groups. We use the concept of 'effective migration' to model the relationship between genetics and geography. In this paradigm, effective migration is low in regions where genetic similarity decays quickly. We present a method to visualize variation in effective migration across a habitat from geographically indexed genetic data. Our approach uses a population genetic model to relate effective migration rates to expected genetic dissimilarities. We illustrate its potential and limitations using simulations and data from elephant, human and Arabidopsis thaliana populations. The resulting visualizations highlight important spatial features of population structure that are difficult to discern using existing methods for summarizing genetic variation.

Indexed as

Models, GeneticSoftwareAnimal MigrationAnimalsArabidopsisElephantsGene FlowGenetics, PopulationHumansMicrosatellite RepeatsMonte Carlo MethodTransients and Migrants

Identifiers

PMID26642242
PMCPMC4696895

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.