ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2016
Genomic divergence and brain evolution: How regulatory DNA influences development of the cerebral cortex.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- A Systematic Review of the Human Accelerated Regions in Schizophrenia and Related Disorders: Where the Evolutionary and Neurodevelopmental Hypotheses Converge.International journal of molecular sciences · 2023Pooled it
- The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex.The EMBO journal · 2024Article
- The evolutionary origin of psychosis.Frontiers in psychiatry · 2023Article
- Enhancer Function and Evolutionary Roles of Human Accelerated Regions.Annual review of genetics · 2022Review
- Article
- Orientation pinwheels in primary visual cortex of a highly visual marsupial.Science advances · 2022Article
- Keeping the balance: Trade-offs between human brain evolution, autism, and schizophrenia.Frontiers in genetics · 2022Review
- Nine Levels of Explanation : A Proposed Expansion of Tinbergen's Four-Level Framework for Understanding the Causes of Behavior.Human nature (Hawthorne, N.Y.) · 2021Article
- The Ferret as a Model System for Neocortex Development and Evolution.Frontiers in cell and developmental biology · 2021Review
- Roots of the Malformations of Cortical Development in the Cell Biology of Neural Progenitor Cells.Frontiers in neuroscience · 2021Review
- Genetic Mechanisms Underlying Cortical Evolution in Mammals.Frontiers in cell and developmental biology · 2021Review
- Evolution and transition of expression trajectory during human brain development.BMC evolutionary biology · 2020Article
- De novo damaging variants associated with congenital heart diseases contribute to the connectome.Scientific reports · 2020Article
- Molecular and cellular evolution of corticogenesis in amniotes.Cellular and molecular life sciences : CMLS · 2020Review
- Article
- Recent advances in understanding neocortical development.F1000Research · 2019Review
- 'Evolutionary medicine' perspectives on Alzheimer's Disease: Review and new directions.Ageing research reviews · 2018Review
- Enhancing our brains: Genomic mechanisms underlying cortical evolution.Seminars in cell & developmental biology · 2018Review
- Epigenetic and Transcriptional Pre-patterning-An Emerging Theme in Cortical Neurogenesis.Frontiers in neuroscience · 2018Review
- Human Accelerated Regions and Other Human-Specific Sequence Variations in the Context of Evolution and Their Relevance for Brain Development.Genome biology and evolution · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The cerebral cortex controls our most distinguishing higher cognitive functions. Human-specific gene expression differences are abundant in the cerebral cortex, yet we have only begun to understand how these variations impact brain function. This review discusses the current evidence linking non-coding regulatory DNA changes, including enhancers, with neocortical evolution. Functional interrogation using animal models reveals converging roles for our genome in key aspects of cortical development including progenitor cell cycle and neuronal signaling. New technologies, including iPS cells and organoids, offer potential alternatives to modeling evolutionary modifications in a relevant species context. Several diseases rooted in the cerebral cortex uniquely manifest in humans compared to other primates, thus highlighting the importance of understanding human brain differences. Future studies of regulatory loci, including those implicated in disease, will collectively help elucidate key cellular and genetic mechanisms underlying our distinguishing cognitive traits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.