Evidence map›Paper›PMID 26641877›Full record

ArticlePsychology and aging2016

A culture-brain link: Negative age stereotypes predict Alzheimer's disease biomarkers.

Becca R Levy, Luigi Ferrucci, Alan B Zonderman, Martin D Slade, Juan Troncoso, Susan M Resnick

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Psychology and aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
34.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 188 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Negative Aging Stereotypes Impair Performance on Brief Cognitive Tests Used to Screen for Predementia.The journals of gerontology. Series B, Psychological sciences and social sciences · 2017
    Trial
  4. Article
  5. Review
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  7. Article
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  9. HCI and Older Adults: The Critical Turn and What Comes Next.Foundations and trends in human computer interaction · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Community-level age bias and older adult mortality.Social science & medicine (1982) · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Becca R LevySocial and Behavioral Sciences Division, School of Public Health, Yale University.
Luigi FerrucciLongitudinal Studies Section, Translational Gerontology Branch, Gerontology Research Center, National Institute on Aging.
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging.
Martin D SladeDepartment of Medicine, School of Medicine, Yale University.
Juan TroncosoDepartments of Pathology and Neurology, Johns Hopkins Medical School.
Susan M ResnickLaboratory of Behavioral Neuroscience, National Institute on Aging.
National Institute on Aging · USYale University · USInstitute on Aging · US

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
Neuroimaging Predictors of Cognitive Decline, Impairment, and ResilienceZIAAG000191 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$26.4M
Early Markers of Alzheimer DiseaseZIAAG000185 · NIA · NATIONAL INSTITUTE ON AGING · PI WALKER, KEENAN · 2009 to 2025
$20.4M
Stress Biomarkers as a Potential Link Between Age Beliefs and HealthR01AG032284 · NIA · YALE UNIVERSITY · PI LEVY, BECCA R · 2009 to 2015
$1.2M
CNS Cellular Senescence/Targeting Endothelial SIPSR43AG023993 · NIA · SOCRATECH, LLC · PI CHOW, NIENWEN · 2004 to 2004
$107k
Intramural NIH HHSNIA NIH HHS AG 05146NIA NIH HHS P50 AG005146NIA NIH HHS R01 AG032284NIA NIH HHS R01AG032284NIA NIH HHS R43 AG023993PHS HHS HHSN-260-2004-00012C
6 · The paper itself

Abstract

Although negative age stereotypes have been found to predict adverse outcomes among older individuals, it was unknown whether the influence of stereotypes extends to brain changes associated with Alzheimer's disease. To consider this possibility, we drew on dementia-free participants, in the Baltimore Longitudinal Study of Aging, whose age stereotypes were assessed decades before yearly magnetic resonance images and brain autopsies were performed. Those holding more-negative age stereotypes earlier in life had significantly steeper hippocampal-volume loss and significantly greater accumulation of neurofibrillary tangles and amyloid plaques, adjusting for relevant covariates. These findings suggest a new pathway to identifying mechanisms and potential interventions related to the pathology of Alzheimer's disease.

Indexed as

CulturePessimismStereotypingAgedAged, 80 and overAgingAlzheimer DiseaseAttitudeAutopsyBaltimoreBiomarkersBrainFemaleHumansLongitudinal StudiesMagnetic Resonance AngiographyBiomarkers

Identifiers

PMID26641877
PMCPMC4853823
OpenAlexW2191732090

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.