Evidence map›Paper›PMID 26641853›Full record

ArticleSpine2016

Effect of Expectations on Treatment Outcome for Lumbar Intervertebral Disc Herniation.

Jon D Lurie, Eric R Henderson, Christine M McDonough, Sigurd H Berven, Emily A Scherer, Tor D Tosteson, Anna N A Tosteson, Serena S Hu, James N Weinstein

Abstract read
In one paragraph

Article in Spine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jon D Lurie*The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth College†Department of Orthopaedics‡Department of Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH§Department of Orthopaedics, University of California, San Francisco¶Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth||Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Eric R Henderson
Christine M McDonough
Sigurd H Berven
Emily A Scherer
Tor D Tosteson
Anna N A Tosteson
Serena S Hu
James N Weinstein

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
LOW BACK PAIN--A MULTICENTER RANDOMIZED TRIALU01AR045444 · NIAMS · DARTMOUTH COLLEGE · PI WEINSTEIN, JAMES N · 1999 to 2013
$20.8M
Prognostic Value of Lumbar Spine MRIP60AR048094 · NIAMS · DARTMOUTH COLLEGE · PI TOSTESON, TOR D. · 2003 to 2007
$6.2M
Outcomes Calculators for Informed Decision Making in Back SurgeryP60AR062799 · NIAMS · DARTMOUTH COLLEGE · PI TOSTESON, TOR D · 2012 to 2016
$6.1M
NCI NIH HHS P30 CA023108NIAMS NIH HHS P60 AR048094NIAMS NIH HHS P60 AR062799NIAMS NIH HHS U01 AR045444
6 · The paper itself

Abstract

STUDY

designSecondary analysis of randomized and nonrandomized prospective cohorts.

objectiveTo examine the effect of patient treatment expectations on treatment outcomes for patients with intervertebral disc herniation. SUMMARY OF BACKGROUND DATA: Patient expectations about treatment effectiveness may have important relationships with clinical outcomes.

methodsSubgroup and reanalysis of the Spine Patient Outcomes Research Trial, a randomized trial and comprehensive cohort study enrolling patients between March 2000 and November 2004 from 13 multidisciplinary spine clinics in 11 US states. Overall, 501 randomized and 744 observational patients (1244 total) who were surgical candidates with radiculopathy and imaging confirmed lumbar intervertebral disc herniation were enrolled. The primary study compared surgical discectomy to usual nonoperative care; this subgroup analysis reassessed outcomes on the basis of treatment expectations at baseline. Expectations about symptomatic and functional improvement for both surgery and nonoperative care were assessed on 5-point scales (1="No Chance (0%)" to 5="Certain (100%)"). Outcomes were assessed using longitudinal regression models analyzed by treatment received.

resultsAmong 1244 IDH SPORT participants, 1168 provided data on both outcomes and baseline expectations and were included in the current analysis: 467 from the randomized and 701 from the observational cohort. Low expectations of outcomes with surgery predicted poorer outcome regardless of treatment. High expectations of outcomes with nonoperative care predicted better nonoperative outcomes but did not affect surgical results. These differences were of similar magnitude to the difference in outcomes between surgery and nonoperative care.

conclusionHigh expectations of treatment benefit had clinically significant positive associations with outcomes. LEVEL OF EVIDENCE: 2.

Indexed as

Anticipation, PsychologicalCohort StudiesFemaleHumansIntervertebral Disc DisplacementLumbar VertebraeMaleMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicTreatment Outcome

Identifiers

PMID26641853
PMCPMC4853251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.