Evidence map›Paper›PMID 26641646›Full record

GuidelineObesity facts2015

European Guidelines for Obesity Management in Adults.

Volkan Yumuk, Constantine Tsigos, Martin Fried, Karin Schindler, Luca Busetto, Dragan Micic, Hermann Toplak, Obesity Management Task Force of the European Association for the Study of Obesity

Erratum issued 10 registry-linked trialsOpen access · goldAbstract readPractice Guideline
In one paragraph

Guideline in Obesity facts, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 10 registered trials, which are not on this map. Cited by 657 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
657citing papers in PubMed, 14 pooled it
228.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06000462 phase4active not recruitingstarted 2024, after this paper: background citation

The Effect of Sodium Glucose Co-transporter 2 Inhibitor (dapagliflozin) on Weight Loss in Non-diabetic Adults with Obesity: Triple-blinded, Randomized, Placebo-controlled Trial.

Ran2024Enrolled150Registered outcomes4Posted comparisons0ConditionsDapagliflozin Adverse Reaction, Effect of Drug, Obesity, Weight LossArmsDapagliflozin 10mg Tab, Metformin 1000 mg (ttd), Placebo
Open the trial in the graph
NCT06287307 phase4not yet recruitingstarted 2024, after this paper: background citation

Semaglutide 2.4mg for Low Responders After Bariatric Surgery

Ran2024Enrolled152Registered outcomes55Posted comparisons0ConditionsObesity, Obesity, Morbid, Weight GainArmsPlacebo, Semaglutide 2.4 MG/0.75 ML Subcutaneous Solution [WEGOVY]
Open the trial in the graph
NCT04360148 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Randomized-controlled Study for Evaluation of Ketogenic Metabolic Nutritional Pattern in Subjects With High-frequency Episodic Migraine

TypeinterventionalSponsorNew Penta SRLRan2020 to 2021Enrolled58ConditionsMigraine, Ketogenic Dieting, Weight Loss, OverweightArmsvery-low-calorie-ketogenic-diet, hypocaloric-balanced-diet
NCT04526847 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effectiveness of Intermittent Fasting Compared to Continuous Energy Restriction on Body Weight Loss Among Overweight/Obese Adults: a Randomized Controlled Trial

TypeinterventionalSponsorArmed Police Force Hospital, NepalRan2023 to 2023Enrolled112ConditionsOverweight and ObesityArmsIntermittent energy restriction (IER) : 5:2 diet pattern, Continuous energy restricted (CER) group
NCT04602572 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Obesity and Oral Diseases in Adult Patients

TypeobservationalSponsorUniversity of BergenRan2026 to 2027Enrolled400ConditionsObesity, Oral Diseases, Periodontitis, Dental CariesArmsLifestyle course., Bariatric surgery.
NCT05394779 nacompletednot on this mapstarted 2022, after this paper: background citation

Evaluation of Performance and Safety of DTXO App, an Innovative Digital Therapy, in Improving Weight Loss and Weight-Loss Maintenance of Patients With Obesity by Increasing Their Adherence to Dietary, Exercise Regimens and Psycho-Behavioral Program

TypeinterventionalSponsorAdvice Pharma Group srlRan2022 to 2024Enrolled246ConditionsObesity, Health Behavior, Life Style, Dietary HabitsArmsDTXO APP, PLACEBO APP - Control group
NCT06164119 naunknown statusnot on this mapstarted 2023, after this paper: background citation

A Randomised Effectiveness-implementation Trial for Evaluating Dietary and Manual Treatment With Osteopathic Techniques on Quality of Life and on Modulation of the Inflammatory State of Patients Diagnosed With Breast Cancer Undergoing Antiestrogenic Hormonal Treatment.

TypeinterventionalSponsorFondazione IRCCS Istituto Nazionale dei Tumori, MilanoRan2023 to 2025Enrolled600ConditionsBreast CancerArmsmanual treatment with osteopathic techniques and nutritional treatment, manual treatment with osteopathic techniques, nutritional treatment
NCT06444711 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

A Randomised Clinical Trial for OPTIMISation of Cardio-renal-metabolic-pulmonary Disease Guideline Adherence in High Risk Community Dwelling Individuals and Evaluation of Outcomes

TypeinterventionalSponsorUniversity of LeedsRan2025 to 2045Enrolled138ConditionsCardiovascular Diseases, Renal Disease, Metabolic Disease, Pulmonary DiseaseArmsNICE guidance
NCT06813170 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Diet With or Without Metarecod® in Obese Subjects With Type 2 Diabetes: Effect on Body Weight, in Vivo Oxidative Stress, Endothelial Function, Low-grade Inflammation and Gut Microbiota

TypeinterventionalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2025 to 2027Enrolled180ConditionsType 2 DiabetesArmsMetarecod, Diet
NCT07240246 nacompletednot on this mapstarted 2025, after this paper: background citation

Effect of a Dietary Supplement (FitLine TopShape) on the Incretin Response

TypeinterventionalSponsorFFoQSI - Austrian Competence Centre for Feed and Food Quality, Safety & InnovationRan2025 to 2026Enrolled40ConditionsGLP-1, Obesity &Amp, Overweight, Dietary SupplementArmsIntervention: Dietary Supplement with Plant Extracts, Placebo
3 · Its place in the literature

Who cites it

657 citing papers in PubMed, 14 syntheses or guidelines pooled it, 3,370 citations in OpenAlex.

  1. Pooled it
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  3. Effect of Citrus bergamia Supplementation on Body Composition in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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  11. Guideline
  12. Comparative effectiveness of semaglutideFrontiers in pharmacology · 2025
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  15. Trial
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597 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 5 countries.

Volkan YumukDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
Constantine Tsigos
Martin Fried
Karin Schindler
Luca Busetto
Dragan Micic
Hermann Toplak
Obesity Management Task Force of the European Association for the Study of Obesity
Charles University · CZHarokopio University of Athens · GRInstitute of Endocrinology · CZIstanbul University-Cerrahpaşa · TRMedical University of Graz · ATMedical University of Vienna · ATUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a chronic metabolic disease characterised by an increase of body fat stores. It is a gateway to ill health, and it has become one of the leading causes of disability and death, affecting not only adults but also children and adolescents worldwide. In clinical practice, the body fatness is estimated by BMI, and the accumulation of intra-abdominal fat (marker for higher metabolic and cardiovascular disease risk) can be assessed by waist circumference. Complex interactions between biological, behavioural, social and environmental factors are involved in regulation of energy balance and fat stores. A comprehensive history, physical examination and laboratory assessment relevant to the patient's obesity should be obtained. Appropriate goals of weight management emphasise realistic weight loss to achieve a reduction in health risks and should include promotion of weight loss, maintenance and prevention of weight regain. Management of co-morbidities and improving quality of life of obese patients are also included in treatment aims. Balanced hypocaloric diets result in clinically meaningful weight loss regardless of which macronutrients they emphasise. Aerobic training is the optimal mode of exercise for reducing fat mass while a programme including resistance training is needed for increasing lean mass in middle-aged and overweight/obese individuals. Cognitive behavioural therapy directly addresses behaviours that require change for successful weight loss and weight loss maintenance. Pharmacotherapy can help patients to maintain compliance and ameliorate obesity-related health risks. Surgery is the most effective treatment for morbid obesity in terms of long-term weight loss. A comprehensive obesity management can only be accomplished by a multidisciplinary obesity management team. We conclude that physicians have a responsibility to recognise obesity as a disease and help obese patients with appropriate prevention and treatment. Treatment should be based on good clinical care, and evidence-based interventions; should focus on realistic goals and lifelong multidisciplinary management.

Indexed as

Disease ManagementAdipose TissueAdultBehavior TherapyBody Mass IndexComorbidityDietEnergy MetabolismEuropeExerciseFemaleHumansObesityWaist CircumferenceWeight Loss

Identifiers

PMID26641646
PMCPMC5644856
OpenAlexW2192722195

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

and 4 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.