ArticleInvestigative ophthalmology & visual science2015
The Connective Tissue Components of Optic Nerve Head Cupping in Monkey Experimental Glaucoma Part 1: Global Change.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 47 citations in OpenAlex.
- The Strain Response to Intraocular Pressure Decrease in the Lamina Cribrosa of Patients with Glaucoma.Ophthalmology. GlaucomaTrial
- Retrolaminar Demyelination of Structurally Intact Axons in Nonhuman Primate Experimental Glaucoma.Investigative ophthalmology & visual science · 2024Article
- Scheimpflug-Based Corneal Biomechanical Analysis As A Predictor of Glaucoma in Eyes With High Myopia.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Evaluation of Spatially Targeted Scleral Stiffening on Neuroprotection in a Rat Model of Glaucoma.Translational vision science & technology · 2022Article
- Morphologic Changes in the Lamina Cribrosa Upon Intraocular Pressure Lowering in Patients With Normal Tension Glaucoma.Investigative ophthalmology & visual science · 2022Article
- The effect of central corneal thickness on Goldmann tonometry: a retrospective study.International ophthalmology · 2022Article
- Strain by virtual extensometers and video-imaging optical coherence tomography as a repeatable metric for IOP-Induced optic nerve head deformations.Experimental eye research · 2021Article
- Corneal Biomechanical Assessment with Ultra-High-Speed Scheimpflug Imaging During Non-Contact Tonometry: A Prospective Review.Clinical ophthalmology (Auckland, N.Z.) · 2021Review
- Biomechanics of the optic nerve head and peripapillary sclera in a mouse model of glaucoma.Journal of the Royal Society, Interface · 2020Article
- Quantification of Translaminar Pressure Gradient (TLPG) With Continuous Wireless Telemetry in Nonhuman Primates (NHPs).Translational vision science & technology · 2020Article
- Connective Tissue Remodeling in Myopia and its Potential Role in Increasing Risk of Glaucoma.Current opinion in biomedical engineering · 2020Article
- Differentiation of Nonarteritic Anterior Ischemic Optic Neuropathy from Normal Tension Glaucoma by Comparison of the Lamina Cribrosa.Investigative ophthalmology & visual science · 2020Article
- Lamina Cribrosa Moves Anteriorly After Trabeculectomy in Myopic Eyes.Investigative ophthalmology & visual science · 2020Article
- Comparison of Lamina Cribrosa Morphology in Normal Tension Glaucoma and Autosomal-Dominant Optic Atrophy.Investigative ophthalmology & visual science · 2020Article
- Article
- OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness, and Minimum Cross-Sectional Area in Healthy Eyes.American journal of ophthalmology · 2019Article
- Age-Dependent Variation of Lamina Cribrosa Displacement During the Standardized Valsalva Maneuver.Scientific reports · 2019Article
- Neuroprotective strategies for retinal disease.Progress in retinal and eye research · 2018Review
- Protruded retinal layers within the optic nerve head neuroretinal rim.Acta ophthalmologica · 2018Article
- Racioethnic Differences in Human Posterior Scleral and Optic Nerve Stump Deformation.Investigative ophthalmology & visual science · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo characterize optic nerve head (ONH) connective tissue change within 21 monkey experimental glaucoma (EG) eyes, so as to identify its principal components.
methodsAnimals were imaged three to five times at baseline then every 2 weeks following chronic unilateral IOP elevation, and euthanized early through end-stage confocal scanning laser tomographic change. Optic nerve heads were serial-sectioned, three-dimensionally (3D) reconstructed, delineated, and quantified. Overall EG versus control eye differences were assessed by general estimating equations (GEE). Significant, animal-specific, EG eye change was required to exceed the maximum physiologic intereye differences in six healthy animals.
resultsOverall EG eye change was significant (P < 0.0026) and animal-specific EG eye change most frequent, for five phenomena (number of EG eyes and range of animal-specific change): posterior laminar deformation (21, -29 to -437 μm), laminar thickening (11, 20-73 μm) and thinning (3, -23 to -31 μm), scleral canal expansion (17, 20-139 μm), outward anterior (16, -16 to -124 μm) and posterior (17, -22 to -279 μm) laminar insertion migration, and peripapillary scleral bowing (11, 21-77 μm). Experimental glaucoma versus control eye laminar thickness differences were bimodal in behavior, being thickened in most EG eyes demonstrating the least deformation and less thickened or thinned in most EG eyes demonstrating the greatest deformation.
conclusionsOur postmortem studies retrospectively identify five connective tissue components of ONH "cupping" in monkey EG which serve as targets for longitudinally staging and phenotyping ONH connective tissue alteration within all forms of monkey and human optic neuropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.