Evidence map›Paper›PMID 26641212›Full record

Observational studyClinical endocrinology2016

Testosterone and cardiac mass and function in men with type 1 diabetes in the Epidemiology of Diabetes Interventions and Complications Study (EDIC).

Catherine Kim, Ionut Bebu, Barbara Braffett, Patricia A Cleary, Valerie Arends, Michael Steffes, Hunter Wessells, Trevor Orchard, Aruna V Sarma, DCCT/EDIC Research Group

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Catherine KimDepartments of Medicine, Obstetrics & Gynecology and Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Ionut BebuThe Biostatistics Center, George Washington University, Rockville, MD, USA.
Barbara BraffettThe Biostatistics Center, George Washington University, Rockville, MD, USA.
Patricia A ClearyThe Biostatistics Center, George Washington University, Rockville, MD, USA.
Valerie ArendsDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Michael SteffesDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Hunter WessellsDepartment of Urology, University of Washington, Seattle, WA, USA.
Trevor OrchardDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Aruna V SarmaDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
DCCT/EDIC Research Group
George Washington University · USUniversity of Michigan–Ann Arbor · USUniversity of Minnesota · USUniversity of Pittsburgh · USUniversity of Washington · US

Funding

Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
Epidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Uro-EDICII: Risk and Progression of Urologic Complications in Type 1- DiabetesR01DK083927 · NIDDK · UNIVERSITY OF WASHINGTON · PI SARMA, ARUNA V, WESSELLS, HUNTER · 2009 to 2013
$2.7M
ReproEDIC: Risk and Progression of Reproductive Abnormalities in Type 1 DiabetesDP3DK098129 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KIM, CATHERINE, SARMA, ARUNA V · 2013 to 2013
$803k
UroEDIC III: Mechanisms and Impact of Urological Complications in Type 1 DiabetesR56DK083927 · NIDDK · UNIVERSITY OF WASHINGTON · PI SARMA, ARUNA V, WESSELLS, HUNTER · 2016 to 2016
$81k
NIDDK NIH HHS DK076169NIDDK NIH HHS DK083927NIDDK NIH HHS DP3 DK098129NIDDK NIH HHS P30 DK020572NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176NIDDK NIH HHS U24 DK076169
6 · The paper itself

Abstract

objectiveLow testosterone concentrations have been reported to be associated with increased risk of congestive heart failure, but the mechanisms are unclear. Our objective was to examine the relationship between endogenous testosterone and measures of cardiac mass and function among men with type 1 diabetes.

designSecondary analysis of a prospective observational study.

participantsMen (n = 508) in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, the observational follow-up of the Diabetes Control and Complications Trial (DCCT). MEASUREMENTS: Testosterone assessed by liquid chromatography mass spectrometry at EDIC year 10 and cardiac magnetic resonance imaging (CMR) measures at EDIC years 14/15. Linear regression models were used to assess the relationship between testosterone, sex hormone binding globulin (SHBG) and left ventricular (LV) mass, volume, ejection fraction and cardiac index before and after adjustment for age, randomization arm, alcohol and cigarette use, macroalbuminuria, haemoglobin A1c, insulin dose, body mass index, lipids, blood pressure, use of antihypertensive medications and microvascular complications.

resultsIn fully adjusted models, total testosterone concentrations were significantly associated with LV mass (P = 0·014), end-diastolic volume (P = 0·002), end-systolic volume (P = 0·012) and stroke volume (P = 0·022), but not measures of LV function after adjustment for cardiac risk factors. Bioavailable testosterone was associated with LV mass, but not volume or function, while SHBG was associated with volume, but not mass or function.

conclusionsAmong men with type 1 diabetes, higher total testosterone was associated with higher LV mass and volume, but not with function. The clinical significance of this association remains to be established.

Indexed as

Diabetes Mellitus, Type 1HeartMyocardiumTestosteroneAdultDiabetes ComplicationsHeart VentriclesHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRisk FactorsSex Hormone-Binding GlobulinVentricular Dysfunction, LeftSex Hormone-Binding GlobulinTestosterone

Identifiers

PMID26641212
PMCPMC4824167
OpenAlexW2281750820

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.