Evidence map›Paper›PMID 26641078›Full record

ArticleThe journal of knee surgery2016

Biphasic Analysis of Cartilage Stresses in the Patellofemoral Joint.

Brian Jones, Clark T Hung, Gerard Ateshian

Abstract read
In one paragraph

Article in The journal of knee surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Brian JonesDepartment of Mechanical Engineering, Columbia University, New York, New York.
Clark T HungDepartment of Biomedical Engineering, Columbia University, New York, New York.
Gerard AteshianDepartment of Mechanical Engineering, Columbia University, New York, New York.
Columbia University · US

Funding

Finite Elements For Biomechanics And BiophysicsR01GM083925 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI GERARD A. ATESHIAN, JEFFREY A. WEISS · 2008 to 2026
$7.6M
BIOTRIBOLOGY OF DIARTHRODIAL JOINTSR01AR043628 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ATESHIAN, GERARD A. · 2000 to 2013
$3.1M
Optimizing Nutrient Supply in Large Engineered Cartilage Tissue ConstructsR01AR060361 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ATESHIAN, GERARD A., HUNG, CLARK T. · 2010 to 2014
$1.7M
NIAMS NIH HHS R01 AR043628NIAMS NIH HHS R01AR043628NIAMS NIH HHS R01 AR060361NIAMS NIH HHS R01AR060361NIGMS NIH HHS R01 GM083925NIGMS NIH HHS R01GM083925
6 · The paper itself

Abstract

The objective of this study was to examine the state of stress within the solid matrix of articular cartilage in the patellofemoral joint, using anatomically faithful biphasic models of the articular layers, with the joint subjected to physiologic muscle force magnitudes. Finite element models of five joints were created from human cadaver knees. Biphasic sliding contact analyses were performed using FEBio software to analyze the response of the joint from 30 to 60 degrees of knee flexion. Results demonstrated that the collagen matrix always sustains tensile stresses, despite the fact that the articular layers are loaded in compression. The principal direction of maximum solid stresses was consistent with the known orientation of collagen fibrils in cartilage. The magnitudes of these tensile stresses under muscle forces representative of activities of daily living were well below tensile failure stresses reported in the prior literature. Results also hinted that solid matrix stresses were higher in the patellar versus femoral superficial zone. These anatomically correct finite element models predicted outcomes consistent with our understanding of structure-function relationships in articular cartilage, while also producing solid matrix stress estimates not observable from experiments alone, yet highly relevant to our understanding of tissue degeneration.

Indexed as

Activities of Daily LivingAgedAged, 80 and overBiomechanical PhenomenaCadaverCartilage, ArticularCollagenComputer SimulationFemaleFinite Element AnalysisHumansMaleMiddle AgedModels, BiologicalPatellofemoral JointStress, MechanicalCollagen

Identifiers

PMID26641078
PMCPMC4747677
OpenAlexW2288843395

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.