ArticlePloS one2015
Tissue-Specific Contributions of Paternally Expressed Gene 3 in Lactation and Maternal Care of Mus musculus.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- ZFP57 is a regulator of postnatal growth and life-long health.Nature communications · 2026Article
- Article
- PEG3 controls lipogenesis through ACLY.PloS one · 2021Article
- Article
- Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers.Human molecular genetics · 2018Article
- Allele and dosage specificity of the Peg3 imprinted domain.PloS one · 2018Article
- Oxytocin receptor is regulated by Peg3.PloS one · 2018Article
- Circular RNA identified from Peg3 and Igf2r.PloS one · 2018Article
- Article
- PEG3 control on the mammalian MSL complex.PloS one · 2017Article
- Parental and sexual conflicts over the Peg3 imprinted domain.Scientific reports · 2016Article
- A Novel Mutant Allele of Pw1/Peg3 Does Not Affect Maternal Behavior or Nursing Behavior.PLoS genetics · 2016Article
- Alternative promoters of Peg3 with maternal specificity.Scientific reports · 2016Article
- Phylogenetic and Epigenetic Footprinting of the Putative Enhancers of the Peg3 Domain.PloS one · 2016Article
- Sex and Tissue Specificity of Peg3 Promoters.PloS one · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Paternally Expressed Gene 3 (Peg3) is an imprinted gene that controls milk letdown and maternal-caring behaviors. In this study, a conditional knockout allele has been developed in Mus musculus to further characterize these known functions of Peg3 in a tissue-specific manner. The mutant line was first crossed with a germline Cre. The progeny of this cross displayed growth retardation phenotypes. This is consistent with those seen in the previous mutant lines of Peg3, confirming the usefulness of the new mutant allele. The mutant line was subsequently crossed individually with MMTV- and Nkx2.1-Cre lines to test Peg3's roles in the mammary gland and hypothalamus, respectively. According to the results, the milk letdown process was impaired in the nursing females with the Peg3 mutation in the mammary gland, but not in the hypothalamus. This suggests that Peg3's roles in the milk letdown process are more critical in the mammary gland than in the hypothalamus. In contrast, one of the maternal-caring behaviors, nest-building, was interrupted in the females with the mutation in both MMTV- and Nkx2.1-driven lines. Overall, this is the first study to introduce a conditional knockout allele of Peg3 and to further dissect its contribution to mammalian reproduction in a tissue-specific manner.
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