Evidence map›Paper›PMID 26640765›Full record

SynthesisNeuroImage. Clinical2015

Multivariate analyses applied to fetal, neonatal and pediatric MRI of neurodevelopmental disorders.

Jacob Levman, Emi Takahashi

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jacob LevmanDivision of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, 1 Autumn Street #456, Boston, MA 02115, USA ; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Emi TakahashiDivision of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, 1 Autumn Street #456, Boston, MA 02115, USA ; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Athinoula A. Martinos Center for Biomedical Imaging · USMassachusetts General Hospital · US

Funding

Development of Brain Connectivity in Human Fetus, Newborn, and Toddler AgesR01HD078561 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI TAKAHASHI (OKI), EMI · 2014 to 2018
$1.7M
Aberrant Patterns of Human Brain Connectivity and Gyral StructuresR03NS091587 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI TAKAHASHI (OKI), EMI · 2015 to 2016
$177k
NICHD NIH HHS R01 HD078561NICHD NIH HHS R01HD078561NINDS NIH HHS R03 NS091587NINDS NIH HHS R03NS091587
6 · The paper itself

Abstract

Multivariate analysis (MVA) is a class of statistical and pattern recognition methods that involve the processing of data that contains multiple measurements per sample. MVA can be used to address a wide variety of medical neuroimaging-related challenges including identifying variables associated with a measure of clinical importance (i.e. patient outcome), creating diagnostic tests, assisting in characterizing developmental disorders, understanding disease etiology, development and progression, assisting in treatment monitoring and much more. Compared to adults, imaging of developing immature brains has attracted less attention from MVA researchers. However, remarkable MVA research growth has occurred in recent years. This paper presents the results of a systematic review of the literature focusing on MVA technologies applied to neurodevelopmental disorders in fetal, neonatal and pediatric magnetic resonance imaging (MRI) of the brain. The goal of this manuscript is to provide a concise review of the state of the scientific literature on studies employing brain MRI and MVA in a pre-adult population. Neurological developmental disorders addressed in the MVA research contained in this review include autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, schizophrenia and more. While the results of this review demonstrate considerable interest from the scientific community in applications of MVA technologies in pediatric/neonatal/fetal brain MRI, the field is still young and considerable research growth remains ahead of us.

Indexed as

Multivariate AnalysisBrainFetusHumansImage Processing, Computer-AssistedMachine LearningMagnetic Resonance ImagingNeurodevelopmental DisordersBrain MRIFetalMachine learningMultivariate analysisNeonatalPediatric

Identifiers

PMID26640765
PMCPMC4625213
OpenAlexW2130048823

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.