ArticleEcology and evolution2015
The transcriptomic and evolutionary signature of social interactions regulating honey bee caste development.
Article in Ecology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- A propolis-rich hive environment affects redox gene expression and gut microbiota at the individual and social level in honey bees.FEMS microbes · 2026Article
- ACmix-Swin Deep Learning of 4-Day-OldGenes · 2025Article
- The role of gut microbiota-gonadal axis in ovary activation of Asian honey bee (Apis cerana) queens.NPJ biofilms and microbiomes · 2025Article
- Social control drove ant evolution.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Molecular Substrates of Insect Eusociality.Annual review of genetics · 2024Review
- A longitudinal study of queen health in honey bees reveals tissue specific response to seasonal changes and pathogen pressure.Scientific reports · 2024Article
- Gut microbiota-driven regulation of queen bee ovarian metabolism.Microbiology spectrum · 2023Article
- Ecology of Pollen Storage in Honey Bees: Sugar Tolerant Yeast and the Aerobic Social Microbiota.Insects · 2023Article
- A complete absence of indirect genetic effects on brain gene expression in a highly social context.Molecular ecology · 2022Article
- Early Queen Development in Honey Bees: Social Context and Queen Breeder Source Affect Gut Microbiota and Associated Metabolism.Microbiology spectrum · 2022Article
- Social microbiota and social gland gene expression of worker honey bees by age and climate.Scientific reports · 2022Article
- Kin selection for cooperation in natural bacterial populations.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Gene expression during larval caste determination and differentiation in intermediately eusocial bumblebees, and a comparative analysis with advanced eusocial honeybees.Molecular ecology · 2021Article
- Comparative Genomics Identifies Putative Signatures of Sociality in Spiders.Genome biology and evolution · 2020Article
- Transcriptomic basis and evolution of the ant nurse-larval social interactome.PLoS genetics · 2019Article
- Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Comparative analyses of the major royal jelly protein gene cluster in three Apis species with long amplicon sequencing.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- MicroRNAs Associated with Caste Determination and Differentiation in a Primitively Eusocial Insect.Scientific reports · 2017Article
- Accelerated Evolution of Developmentally Biased Genes in the Tetraphenic Ant Cardiocondyla obscurior.Molecular biology and evolution · 2017Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
The caste fate of developing female honey bee larvae is strictly socially regulated by adult nurse workers. As a result of this social regulation, nurse-expressed genes as well as larval-expressed genes may affect caste expression and evolution. We used a novel transcriptomic approach to identify genes with putative direct and indirect effects on honey bee caste development, and we subsequently studied the relative rates of molecular evolution at these caste-associated genes. We experimentally induced the production of new queens by removing the current colony queen, and we used RNA sequencing to study the gene expression profiles of both developing larvae and their caregiving nurses before and after queen removal. By comparing the gene expression profiles of queen-destined versus worker-destined larvae as well as nurses observed feeding these two types of larvae, we identified larval and nurse genes associated with caste development. Of 950 differentially expressed genes associated with caste, 82% were expressed in larvae with putative direct effects on larval caste, and 18% were expressed in nurses with putative indirect effects on caste. Estimated selection coefficients suggest that both nurse and larval genes putatively associated with caste are rapidly evolving, especially those genes associated with worker development. Altogether, our results suggest that indirect effect genes play important roles in both the expression and evolution of socially influenced traits such as caste.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.