ArticleClinics in orthopedic surgery2015
Patterns of Treatment for Metastatic Pathological Fractures of the Spine: The Efficacy of Each Treatment Modality.
Article in Clinics in orthopedic surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Clinical evaluation, diagnosis, and decision-making for metastatic spine tumors: WFNS spine committee recommendations.Neurosurgical review · 2024Pooled it
- Trends and disparities in the surgical management of spinal fractures in Sweden during 2008-2023.BMC musculoskeletal disorders · 2025Article
- Prognostic Factors after Surgical Treatment for Spinal Metastases.Asian spine journal · 2024Article
- The influence of diverse bone cement distribution patterns for metastatic vertebral lesions after bilateral percutaneous kyphoplasty.BMC musculoskeletal disorders · 2022Article
- How do vertebroplasty and kyphoplasty affect the quality of life of patients with multiple myeloma spinal metastasis?European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2020Article
- Observational
- Safety of Cement Distribution Patterns in Metastatic Vertebral Tumors: A Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Innovative Spine Implants for Improved Augmentation and Stability in Neoplastic Vertebral Compression Fracture.Medicina (Kaunas, Lithuania) · 2019Review
- [Metastatic breast cancer in the spine : Molecular predictors for choosing adequate treatment strategies].Der Orthopade · 2018Review
- A review and update of vertebral fractures due to metastatic tumors of various sites to the spine: Percutaneous vertebroplasty.Interventional medicine & applied science · 2018Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetastatic pathological fractures of the spine are a major problem for cancer patients; however, there is no consensus on treatment strategy. The purpose of this study was to evaluate various treatment options by analyzing their patterns for metastatic pathological fractures of the spine.
methodsIn this study, 54 patients (male:female = 36:18) who were diagnosed with metastatic pathological fractures of spine were recruited. Demographic data, origin of cancer, type of treatment, and results were obtained from electronic medical records. Treatment options were divided into radiotherapy (RT), vertebroplasty (VP) or kyphoplasty (KP), operation (OP), and other treatments. Treatment results were defined as aggravation, no response, fair response, good response, and unknown. The survival time after detection of pathologic fractures was analyzed with the Kaplan-Meier method.
resultsThe mean age of the patients was 62.3 years. Hepatocellular carcinoma was the most common cancer of primary origin (n = 9), followed by multiple myeloma (n = 8). RT was the most common primary choice of treatment (n = 29, 53.7%), followed by OP (n = 13, 24.1%), and VP or KP (n = 10, 18.5%). Only 13 of 29 RT cases and 7 of 13 OP cases demonstrated a fair or good response. The mean survival time following detection of pathological spinal fractures was 11.1 months for 29 patients, who died during the study period.
conclusionsRT was the most common primary choice of treatment for metastatic pathological fractures of the spine. However, the response rate was suboptimal. Although OP should be considered for the relief of mechanical back pain or neurologic symptoms, care should be taken in determining the surgical indication. VP or KP could be considered for short-term control of localized pain, although the number of cases was too small to confirm the conclusion. It is difficult to determine the superiority of the treatment modalities, hence, a common guideline for the diagnosis and treatment of metastatic pathological fractures of the spine is required.
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