ArticleOxidative medicine and cellular longevity2016
Estrogen Replacement Reduces Oxidative Stress in the Rostral Ventrolateral Medulla of Ovariectomized Rats.
Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Mechanisms of Hypertension in Women: Interactions Between Vascular Ageing, Metabolic Dysfunction, and Hormonal Regulation.Biomedicines · 2026Review
- Comparison of Heart Rate Variability Between Sexes: Impact of a Physically Active Lifestyle.International journal of environmental research and public health · 2026Article
- Neuro-glial mechanisms underlying sex-based resilience to cardiorespiratory dysfunction in heart failure.Clinical science (London, England : 1979) · 2026Article
- Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells.Nature communications · 2025Article
- Estrogen-mediated modulation of sterile inflammatory markers and baroreflex sensitivity in ovariectomized female Wistar rats.Archives of endocrinology and metabolism · 2024Article
- The Local Release of Teriparatide Incorporated in 45S5 Bioglass Promotes a Beneficial Effect on Osteogenic Cells and Bone Repair in Calvarial Defects in Ovariectomized Rats.Journal of functional biomaterials · 2023Article
- Brain nuclear receptors and cardiovascular function.Cell & bioscience · 2023Review
- Fenugreek Seed Ethanolic Extract Improves Alveolar Bone Parameters by Attenuating Inflammation in Ovariectomized Rats.Journal of inflammation research · 2023Article
- Jin-Tian-Ge ameliorates ovariectomy-induced bone loss in rats and modulates osteoblastogenesis and osteoclastogenesis in vitro.Chinese medicine · 2022Article
- Exosomes Derived from BM-MSCs Mitigate the Development of Chronic Kidney Damage Post-Menopause via Interfering with Fibrosis and Apoptosis.Biomolecules · 2022Article
- Maca extracts and estrogen replacement therapy in ovariectomized rats exposed at high altitude.Reproductive medicine and biology · 2021Article
- β-Arrestin1 Reduces Oxidative Stress via Nrf2 Activation in the Rostral Ventrolateral Medulla in Hypertension.Frontiers in neuroscience · 2021Article
- Estrogen-dependent hypersensitivity to diabetes-evoked cardiac autonomic dysregulation: Role of hypothalamic neuroinflammation.Life sciences · 2020Article
- The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat.Cancers · 2020Article
- Ovariectomized rat model of osteoporosis: a practical guide.EXCLI journal · 2020Review
- Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats.Neuroscience bulletin · 2019Article
- Upregulation of Nav1.6 expression in the rostral ventrolateral medulla of stress-induced hypertensive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Rostral Ventrolateral Medulla and Hypertension.Hypertension (Dallas, Tex. : 1979) · 2018Review
- Oxidative stress as a possible pathogenic cofactor of post-menopausal osteoporosis: Existing evidence in support of the axis oestrogen deficiency-redox imbalance-bone loss.The Indian journal of medical research · 2018Review
- Effects of β-estradiol on cold-sensitive receptor channel TRPM8 in ovariectomized rats.Experimental animals · 2017Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease prevalence rises rapidly after menopause, which is believed to be derived from the loss of estrogen. It is reported that sympathetic tone is increased in postmenopause. The high level of oxidative stress in the rostral ventrolateral medulla (RVLM) contributes to increased sympathetic outflow. The focus of this study was to determine if estrogen replacement reduces oxidative stress in the RVLM and sympathetic outflow in the ovariectomized (OVX) rats. The data of this study showed that OVX rat increased oxidative stress in the RVLM and sympathetic tone; estrogen replacement improved cardiovascular functions but also reduced the level of oxidative stress in the RVLM. These findings suggest that estrogen replacement decreases blood pressure and sympathoexcitation in the OVX rats, which may be associated with suppression in oxidative stress in the RVLM through downregulation of protein expression of NADPHase (NOX4) and upregulation of protein expression of SOD1. The data from this study is beneficial for our understanding of the mechanism of estrogen exerting cardiovascular protective effects on postmenopause.
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