Evidence map›Paper›PMID 26640595›Full record

ArticleJournal of Cancer2015

Identification of Regulatory-RNAs for Alternative Splicing of Ron Proto-Oncogene.

Heegyum Moon, Xuexiu Zheng, Tiing Jen Loh, Ha Na Jang, Yongchao Liu, Da-Woon Jung, Darren R Williams, Haihong Shen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Heegyum Moon1These authors contributed equally to this manuscript.
Xuexiu Zheng1These authors contributed equally to this manuscript.
Tiing Jen LohSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea.
Ha Na JangSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea.
Yongchao LiuSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea.
Da-Woon JungSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea.
Darren R WilliamsSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea.
Haihong ShenSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea.
Gwangju Institute of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RON receptor tyrosine kinase is a proto-oncogene that induces cell migration and matrix invasion. RONΔ160 protein, which is produced by exclusion of exon 5 and 6, promotes cell migration, matrix invasion and protection from apoptosis. Alternative splicing regulation of exon 5 and 6 is not well understood. In this manuscript, we identified several new RNA regulatory elements for alternative splicing of Ron proto-oncogene. Firstly, we demonstrated that RNA sequences from EcoRI cleavage sites regulate alternative splicing of Ron exon 5 and 6. Secondly, we showed that the ~30 nt RNA at upstream end of exon 4 and the ~33 nt RNA at downstream end of exon 7 also modulate splicing of exon 5 and 6. Thirdly, our results indicate that the RNA sequences of the ends in exon 4 and 7 are required for the regulatory functions of the RNA from restriction enzyme cleavage sites. Our results provide a new insight for regulation of alternative splicing of Ron proto-oncogene.

Indexed as

exon 5exon 6pre-mRNA splicingRegulatory-RNA sequenceRon

Identifiers

PMID26640595
PMCPMC4643091
OpenAlexW2203444331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.