Evidence map›Paper›PMID 26640529›Full record

ArticleExperimental and therapeutic medicine2015

Effects and mechanism of Xin Mai Jia in a rabbit model of atherosclerosis.

Fan-Rong Zhao, Jun-Xiu Lu, Mei Jia, Ya-Ling Yin, Heng-Tian Qi, Mo-Li Zhu, Li-Juan Ma, LE-LE Qiu, Guang-Ming Wan, Guang-Rui Wan

RetractedOpen access · diamondAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Fan-Rong ZhaoSanquan Medical College, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
Jun-Xiu LuSchool of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
Mei JiaPuyang City Health School, Puyang, Henan 457000, P.R. China.
Ya-Ling YinSchool of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
Heng-Tian QiCardiothoracic Surgery, The Third Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
Mo-Li ZhuSanquan Medical College, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
Li-Juan MaSanquan Medical College, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
LE-LE QiuSchool of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
Guang-Ming WanDepartment of Ophthalmology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Guang-Rui WanSchool of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
Xinxiang Medical University · CNFirst Affiliated Hospital of Zhengzhou University · CNLiuyang City Maternal and Child Health Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to investigate the protective effects of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rabbits and to explore the underlying mechanisms in order to provide experimental evidence for the clinical application of XMJ. An intraperitoneal injection of vitamin D3, combined with a high-fat diet and sacculus injury, was utilized to establish the AS rabbit model. Following the oral administration of lovastatin, Zhibituo and different dosages of XMJ, respectively, blood was drawn from each rabbit for the detection of blood rheological indicators, such as serum lipids. The pathological changes in the right common carotid artery were observed. Vascular function experiments and the expression detection of common carotid artery-related proteins by immunohistochemistry were conducted. XMJ was observed to decrease the blood lipid levels of the AS rabbits; increase the concentration of high-density lipoprotein and apolipoprotein A; decrease blood viscosity, erythrocyte sedimentation rate and hematocrit; elevate the levels of endothelial nitric oxide synthase (eNOS) and Na

Indexed as

atherosclerosishyperlipidemiaXin Mai Jia

Identifiers

PMID26640529
PMCPMC4665141
OpenAlexW2125527965

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.