ReviewFrontiers in human neuroscience2015
A Hierarchical Generative Framework of Language Processing: Linking Language Perception, Interpretation, and Production Abnormalities in Schizophrenia.
Review in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neuropsychological dimensions related to alterations of verbal self-monitoring neural networks in schizophrenic language: systematic review.Frontiers in psychiatry · 2024Pooled it
- Meta-analysis of human prediction error for incentives, perception, cognition, and action.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Central auditory processing deficits in schizophrenia: Effects of auditory-based cognitive training.Schizophrenia research · 2021Trial
- CDP-choline and galantamine, a personalized α7 nicotinic acetylcholine receptor targeted treatment for the modulation of speech MMN indexed deviance detection in healthy volunteers: a pilot study.Psychopharmacology · 2020Trial
- Motivational Interviewing Produces Change Talk in Smokers with Serious Mental Illness.Journal of dual diagnosisTrial
- Apical integration theory provides a neural basis for understanding disorganization and consciousness in the schizophrenias.Current research in neurobiology · 2026Article
- Neurophysiological Correlates of Target-Related Visual Attention Processes as a Function of Reward in Connection with Schizotypy.Brain topography · 2026Article
- Turn-taking fluency in free conversations with individuals diagnosed with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Binomial order is a speech marker of psychosis and thought disorder.Scientific reports · 2025Article
- Weaker top-down cognitive control and stronger bottom-up signaling transmission as a pathogenesis of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Pre-Stimulus Activity of Left and Right TPJ in Linguistic Predictive Processing: A MEG Study.Brain sciences · 2024Article
- Early auditory processing abnormalities alter individual learning trajectories and sensitivity to computerized cognitive training in schizophrenia.Psychological medicine · 2024Article
- A predictive coding model of the N400.Cognition · 2024Article
- Flexibility Retained: Unimpaired Updating of Expectations in Schizophrenia.Behavioral sciences (Basel, Switzerland) · 2024Article
- Theory-Driven Analysis of Natural Language Processing Measures of Thought Disorder Using Generative Language Modeling.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Controllability of Functional Brain Networks and Its Clinical Significance in First-Episode Schizophrenia.Schizophrenia bulletin · 2023Article
- Language Network Dysfunction and Formal Thought Disorder in Schizophrenia.Schizophrenia bulletin · 2023Review
- Linguistic findings in persons with schizophrenia-a review of the current literature.Frontiers in psychology · 2023Review
- Construct validity for computational linguistic metrics in individuals at clinical risk for psychosis: Associations with clinical ratings.Schizophrenia research · 2022Article
- We both say tomato: Intact lexical alignment in schizophrenia and bipolar disorder.Schizophrenia research · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Language and thought dysfunction are central to the schizophrenia syndrome. They are evident in the major symptoms of psychosis itself, particularly as disorganized language output (positive thought disorder) and auditory verbal hallucinations (AVHs), and they also manifest as abnormalities in both high-level semantic and contextual processing and low-level perception. However, the literatures characterizing these abnormalities have largely been separate and have sometimes provided mutually exclusive accounts of aberrant language in schizophrenia. In this review, we propose that recent generative probabilistic frameworks of language processing can provide crucial insights that link these four lines of research. We first outline neural and cognitive evidence that real-time language comprehension and production normally involve internal generative circuits that propagate probabilistic predictions to perceptual cortices - predictions that are incrementally updated based on prediction error signals as new inputs are encountered. We then explain how disruptions to these circuits may compromise communicative abilities in schizophrenia by reducing the efficiency and robustness of both high-level language processing and low-level speech perception. We also argue that such disruptions may contribute to the phenomenology of thought-disordered speech and false perceptual inferences in the language system (i.e., AVHs). This perspective suggests a number of productive avenues for future research that may elucidate not only the mechanisms of language abnormalities in schizophrenia, but also promising directions for cognitive rehabilitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.