Evidence map›Paper›PMID 26640290›Full record

ArticleGeburtshilfe und Frauenheilkunde2012

Biomarkers in Breast Cancer - An Update.

M Schmidt, P A Fasching, M W Beckmann, H Kölbl

Open access · bronzeAbstract read
In one paragraph

Article in Geburtshilfe und Frauenheilkunde, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 46 citations in OpenAlex.

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  20. Epidemiology of Breast Cancer - Current Figures and Trends.Geburtshilfe und Frauenheilkunde · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

M SchmidtKlinik für Geburtshilfe und Frauenkrankheiten, Universitätsmedizin Mainz, Mainz.
P A FaschingFrauenklinik, Universitätsklinikum Erlangen, Erlangen.
M W BeckmannFrauenklinik, Universitätsklinikum Erlangen, Erlangen.
H KölblKlinik für Geburtshilfe und Frauenkrankheiten, Universitätsmedizin Mainz, Mainz.
Johannes Gutenberg University Mainz · DEUniversitätsklinikum Erlangen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The therapy of choice for breast cancer patients requiring adjuvant chemo- or radiotherapy is increasingly guided by the principle of weighing the individual effectiveness of the therapy against the associated side effects. This has only been made possible by the discovery and validation of modern biomarkers. In the last decades and in the last few years some biomarkers have been integrated in clinical practice and a number have been included in modern study concepts. The importance of biomarkers lies not merely in their prognostic value indicating the future course of disease but also in their use to predict patient response to therapy. Due to the many subgroups, mathematical models and computer-assisted analysis are increasingly being used to assess the prognostic information obtained from established clinical and histopathological factors. In addition to describing some recent computer programmes this overview will focus on established molecular markers which have already been extensively validated in clinical practice and on new molecular markers identified by genome-wide studies.

Indexed as

biomarkerbreast cancerHer2/neu (human epidermal growth factor receptor)

Identifiers

PMID26640290
PMCPMC4651165
OpenAlexW2315969174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.