Evidence map›Paper›PMID 26640146›Full record

ArticleOncogene2016

ASXL2 promotes proliferation of breast cancer cells by linking ERα to histone methylation.

U-H Park, M-R Kang, E-J Kim, Y-S Kwon, W Hur, S K Yoon, B-J Song, J H Park, J-T Hwang, J-C Jeong and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. The Disordered Region of ASXL1 Acts as an Auto-Regulator Through Condensation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
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  10. Additional Sex Combs-like Family Associated with Epigenetic Regulation.International journal of molecular sciences · 2024
    Review
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  14. Review
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  18. Article
  19. Review
  20. Molecular Regulation of the Polycomb Repressive-Deubiquitinase.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

U-H ParkDepartment of Bioscience and Biotechnology, Sejong University, Seoul, Korea.
M-R KangBioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Korea.
E-J KimDepartment of Molecular Biology, Dankook University, Gyeonggi-do, Korea.
Y-S KwonDepartment of Bioscience and Biotechnology, Sejong University, Seoul, Korea.
W HurThe Catholic University Liver Research Center and WHO Collaborating Center of Viral Hepatitis, The Catholic University, College of Medicine, Seoul, Korea.
S K YoonThe Catholic University Liver Research Center and WHO Collaborating Center of Viral Hepatitis, The Catholic University, College of Medicine, Seoul, Korea.
B-J SongBreast Center Departments of Surgery, Seoul St. Mary's Hospital College of Medicine, The Catholic University, Seoul, Korea.
J H ParkKorea Food Research Institute, Bundang-gu, Korea.
J-T HwangKorea Food Research Institute, Bundang-gu, Korea.
J-C JeongDepartment of Biochemistry, Molecular Biology and Internal Medicine, College of Oriental Medicine, Dongguk University, Kyungpook, Korea.
S-J UmDepartment of Bioscience and Biotechnology, Sejong University, Seoul, Korea.
Sejong University · KRCatholic University of Korea · KRKorea Food Research Institute · KRDankook University · KRDongguk University · KRKorea Research Institute of Bioscience and Biotechnology · KRSeoul St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estrogen receptor alpha (ERα) has a pivotal role in breast carcinogenesis by associating with various cellular factors. Selective expression of additional sex comb-like 2 (ASXL2) in ERα-positive breast cancer cells prompted us to investigate its role in chromatin modification required for ERα activation and breast carcinogenesis. Here, we observed that ASXL2 interacts with ligand E2-bound ERα and mediates ERα activation. Chromatin immunoprecipitation-sequencing analysis supports a positive role of ASXL2 at ERα target gene promoters. ASXL2 forms a complex with histone methylation modifiers including LSD1, UTX and MLL2, which all are recruited to the E2-responsive genes via ASXL2 and regulate methylations at histone H3 lysine 4, 9 and 27. The preferential binding of the PHD finger of ASXL2 to the dimethylated H3 lysine 4 may account for its requirement for ERα activation. On ASXL2 depletion, the proliferative potential of MCF7 cells and tumor size of xenograft mice decreased. Together with our finding on the higher ASXL2 expression in ERα-positive patients, we propose that ASXL2 could be a novel prognostic marker in breast cancer.

Indexed as

Cell ProliferationAnimalsBiomarkers, TumorBlotting, WesternBreast NeoplasmsDNA-Binding ProteinsEstrogen Receptor alphaFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHEK293 CellsHistone DemethylasesHistonesHumansLysineMCF-7 CellsASXL2 protein, humanBiomarkers, TumorDNA-Binding ProteinsEstrogen Receptor alphaHistone DemethylasesHistonesKDM1A protein, humanKMT2D protein, humanLysineNeoplasm ProteinsRepressor Proteins

Identifiers

PMID26640146
OpenAlexW2190077392

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.