ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2016
Defining knee pain trajectories in early symptomatic knee osteoarthritis in primary care: 5-year results from a nationwide prospective cohort study (CHECK).
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Prognostic Factors and Changes in Pain, Physical Functioning, and Participation in Patients With Hip and/or Knee Osteoarthritis: A Systematic Review.Arthritis care & research · 2025Pooled it
- Prognostic factors associated with changes in knee pain outcomes, identified from initial primary care consultation data. A systematic literature review.Annals of medicine · 2023Pooled it
- Identification of pain categories associated with change in pain in patients receiving placebo: data from two phase 3 randomized clinical trials in symptomatic knee osteoarthritis.BMC musculoskeletal disorders · 2018Pooled it
- SPOT: An Early Detection Tool for Predicting Pain Trajectories Following Intra-Articular Injections.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Trial
- Pain and functional trajectories in symptomatic knee osteoarthritis over up to 12 weeks of exercise exposure.Osteoarthritis and cartilage · 2018Trial
- Association of baseline MRI-defined structural features with knee symptom trajectories over nine years: Data from the osteoarthritis initiative (OAI).Osteoarthritis imaging · 2026Article
- Beyond the algorithms: Challenges in predicting knee osteoarthritis pain from a machine learning point of view.Osteoarthritis imaging · 2026Article
- The global profile of individuals undergoing total knee replacement surgery through a PROGRESS-PLUS equity lens: A systematic review.The South African journal of physiotherapy · 2026Review
- A robust and interpretable deep transfer learning framework on knee acoustic emissions for osteoarthritis classification.npj biomedical innovations · 2026Article
- The association of pain phenotype and providing caregiving with depressive symptom trajectory for older adults: a longitudinal analysis using the health and retirement study.BMC geriatrics · 2025Article
- Longitudinal and transverse muscle stiffness change differently with knee osteoarthritis and do not align with stiffness sensation.Frontiers in physiology · 2025Article
- Association of neighborhood-level disadvantage beyond individual sociodemographic factors in patients with or at risk of knee osteoarthritis.BMC musculoskeletal disorders · 2024Article
- Measurement of Pain Frequency Associated With Knee Osteoarthritis: Future Directions.The journal of pain · 2024Article
- Assessing the Value of Imaging Data in Machine Learning Models to Predict Patient-Reported Outcome Measures in Knee Osteoarthritis Patients.Bioengineering (Basel, Switzerland) · 2024Article
- Identifying Weekly Trajectories of Pain Severity Using Daily Data From an mHealth Study: Cluster Analysis.JMIR mHealth and uHealth · 2024Article
- Clinical Assessment of Osteoarthritis Pain: Contemporary Scenario, Challenges, and Future Perspectives.Pain and therapy · 2024Review
- Exploring different models of pain phenotypes and their association with pain worsening in people with early knee osteoarthritis: The MOST cohort study.Osteoarthritis and cartilage · 2024Article
- Societal beliefs about pain may be more balanced than previously thought. Results of the Guernsey pain survey.BMC musculoskeletal disorders · 2024Observational
- [Concept for integrative pain treatment of osteoarthritis of the knee based on the evidence for conservative and complementary therapies].Schmerz (Berlin, Germany) · 2023Review
- The Natural History of Knee Osteoarthritis Pain Experience and Risk Profiles.The journal of pain · 2023Observational
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGPs have high consultation rates for symptoms related to knee osteoarthritis (OA). Many risk factors for symptomatic knee OA progression remain unknown.
aimTo define distinct knee pain trajectories in individuals with early symptomatic knee OA and determine the risk factors for these pain trajectories. DESIGN AND
settingData were obtained from the multicentre prospective Cohort Hip and Cohort Knee study in the Netherlands. Participants with knee OA, according to the clinical criteria of the American College of Rheumatology, and a completed 5-year follow-up were included.
methodBaseline demographic, anamnestic, and physical examination characteristics were assessed. Outcome was annually assessed by the Numeric Rating Scale for pain. Pain trajectories were retrieved by latent class growth analysis. Multinomial logistic regression was used to calculate relative risk ratios.
resultsIn total, 705 participants were included. Six distinct pain trajectories were identified with favourable and unfavourable courses. Statistically significant differences were found in baseline characteristics, including body mass index (BMI), symptom severity, and pain coping strategies between the different trajectories. Higher BMI, lower level of education, greater comorbidity, higher activity limitation scores, and joint space tenderness were more often associated with trajectories characterised by more pain at first presentation and pain progression--compared with the reference group with a mild pain trajectory. No association was found for baseline radiographic features.
conclusionThese results can help differentiate those patients who require more specific monitoring in the management of early symptomatic knee OA from those for whom a 'wait-and-see' policy seems justifiable. Radiography provided no additional benefit over clinical diagnosis of early symptomatic knee OA in general practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.