ArticleScientific reports2015
Superdiffusive motion of membrane-targeting C2 domains.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Missense mutations on SynGAP C2 domain impair membrane diffusion.Protein science : a publication of the Protein Society · 2026Article
- Dynamic relocation of PKA regulatory subunits during sperm capacitation: Linking PKA to the CatSper signaling complex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reorganization of the flagellum scaffolding induces a sperm standstill during fertilization.eLife · 2024Article
- Non-Markovian Diffusion and Adsorption-Desorption Dynamics: Analytical and Numerical Results.Entropy (Basel, Switzerland) · 2024Article
- Dissecting the biophysical mechanisms of oleate hydratase association with membranes.Frontiers in molecular biosciences · 2024Article
- Article
- Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions.Nature communications · 2021Article
- Non-Normalizable Quasi-Equilibrium Solution of the Fokker-Planck Equation for Nonconfining Fields.Entropy (Basel, Switzerland) · 2021Article
- Testing of Multifractional Brownian Motion.Entropy (Basel, Switzerland) · 2020Article
- Identifying diffusive motions in single-particle trajectories on the plasma membrane via fractional time-series models.Physical review. E · 2019Article
- Article
- Ergodicity breaking on the neuronal surface emerges from random switching between diffusive states.Scientific reports · 2017Article
- Quantifying non-ergodicity of anomalous diffusion with higher order moments.Scientific reports · 2017Article
- Dynamic interactions between a membrane binding protein and lipids induce fluctuating diffusivity.Science advances · 2017Article
- Computational and theoretical approaches for studies of a lipid recognition protein on biological membranes.Biophysics and physicobiology · 2017Review
- Strange kinetics of bulk-mediated diffusion on lipid bilayers.Physical chemistry chemical physics : PCCP · 2016Article
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Authors and funding
5 authors.
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Abstract
Membrane-targeting domains play crucial roles in the recruitment of signalling molecules to the plasma membrane. For most peripheral proteins, the protein-to-membrane interaction is transient. After proteins dissociate from the membrane they have been observed to rebind following brief excursions in the bulk solution. Such membrane hops can have broad implications for the efficiency of reactions on membranes. We study the diffusion of membrane-targeting C2 domains using single-molecule tracking in supported lipid bilayers. The ensemble-averaged mean square displacement (MSD) exhibits superdiffusive behaviour. However, traditional time-averaged MSD analysis of individual trajectories remains linear and does not reveal superdiffusion. Our observations are explained in terms of bulk excursions that introduce jumps with a heavy-tail distribution. These hopping events allow proteins to explore large areas in a short time. The experimental results are shown to be consistent with analytical models of bulk-mediated diffusion and numerical simulations.
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