ArticleScientific reports2015
Infectious Progeny of 2009 A (H1N1) Influenza Virus Replicated in and Released from Human Neutrophils.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Pathway mapping of leukocyte transcriptome in influenza patients reveals distinct pathogenic mechanisms associated with progression to severe infection.BMC medical genomics · 2020Trial
- Pandemic influenza A (H1N1) virus causes abortive infection of primary human T cells.Emerging microbes & infections · 2022Article
- Patient hematology during hospitalization for viral pneumonia caused by SARS-CoV-2 and non-SARS-CoV-2 agents: a retrospective study.European journal of medical research · 2021Article
- Recent Advances in Quenchbody, a Fluorescent Immunosensor.Sensors (Basel, Switzerland) · 2021Review
- Host DNA released by NETosis in neutrophils exposed to seasonal H1N1 and highly pathogenic H5N1 influenza viruses.Respiratory research · 2020Article
- The role of platelets in mediating a response to human influenza infection.Nature communications · 2019Article
- The Role of Innate Leukocytes during Influenza Virus Infection.Journal of immunology research · 2019Review
- Single-Step Detection of the Influenza Virus Hemagglutinin Using Bacterially-Produced Quenchbodies.Sensors (Basel, Switzerland) · 2018Article
- The inflammatory response triggered by Influenza virus: a two edged sword.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Review
- Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various reports have indicated that a number of viruses could infect neutrophils, but the multiplication of viruses in neutrophils was abortive. Based on our previous finding that avian influenza viral RNA and proteins were present in the nucleus of infected human neutrophils in vivo, we investigated the possibility of 2009 A (H1N1) influenza viral synthesis in infected neutrophils and possible release of infectious progeny from host cells. In this study we found that human neutrophils in vitro without detectable level of sialic acid expression could be infected by this virus strain. We also show that the infected neutrophils can not only synthesize 2009 A (H1N1) viral mRNA and proteins, but also produce infectious progeny. These findings suggest that infectious progeny of 2009 A (H1N1) influenza virus could be replicated in and released from human neutrophils with possible clinical implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.