ArticleEuropean journal of nuclear medicine and molecular imaging2016
Relationship between left ventricular diastolic function and myocardial sympathetic denervation measured by (123)I-meta-iodobenzylguanidine imaging in Anderson-Fabry disease.
Article in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Cardiac involvement in Anderson-Fabry disease. The role of advanced echocardiography.Frontiers in cardiovascular medicine · 2024Review
- Detection of sympathetic denervation defects in Fabry disease by hybrid [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Impairment of sympathetic activity in Fabry disease cardiomyopathy: A further challenge for cardiac imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- New insights for early assessment of cardiac involvement in Anderson-Fabry disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Review
- Focal reduction in left ventricularJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Anderson-Fabry Disease: From Endothelial Dysfunction to Emerging Therapies.Advances in pharmacological and pharmaceutical sciences · 2021Review
- Left ventricular radial strain impairment precedes hypertrophy in Anderson-Fabry disease.The international journal of cardiovascular imaging · 2020Article
- Relationships between left ventricular sympathetic innervation and diastolic dysfunction: the role of myocardial innervation/perfusion mismatch.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Evaluation of Ventricular Diastolic Function in Patients With Fibromyalgia Syndrome.Archives of rheumatology · 2018Article
- Cardiac sympathetic neuronal damage precedes myocardial fibrosis in patients with Anderson-Fabry disease.European journal of nuclear medicine and molecular imaging · 2017Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWhether cardiac sympathetic nervous function abnormalities may be present in patients with Anderson-Fabry disease (AFD) remains unexplored. We investigated the relationship between left ventricular (LV) function and cardiac sympathetic nervous function in patients with AFD.
methodsTwenty-five patients (12 men, mean age 43 ± 13 years) with genetically proved AFD and preserved LV ejection fraction and ten age and gender-matched control subjects underwent speckle tracking echocardiography and (123)I-meta-iodobenzylguanidine (MIBG) imaging from which early and late heart to mediastinum (H/M) ratios and myocardial washout rate values were calculated.
resultsIn AFD patients, a significant correlation between late H/M ratio and LV mass index (r = -61, p = 0.001), left atrial volume (r = -0.72, p < 0.001), systolic pulmonary artery pressure (r = -0.75, p < 0.001), and early diastolic untwisting rate (r = -0.66, p < 0.001) was found. Ten AFD patients exhibited a late H/M ratio below two fold standard deviation of control subjects (≤1.75). Patients showing late H/M ratio ≤ 1.75 had significantly higher LV mass index, relative wall thickness, left atrial volume and systolic pulmonary artery pressure, lower systolic longitudinal strain and an early diastolic untwisting rate compared to patients with late H/M ratio > 1.75. At multivariable linear regression analysis, early diastolic untwisting rate was the only independent predictor of late H/M ratio ≤ 1.75 (odds ratio 1.15, 95 % confidence interval 1.07-1.31, p < 0.05).
conclusionThe present findings provide the first demonstration of a cardiac sympathetic derangement in AFD patients with preserved LV ejection fraction, which is mostly related to LV diastolic dysfunction.
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