SynthesisJournal of preventive medicine and public health = Yebang Uihakhoe chi2015
Hormonal Replacement Therapy and the Risk of Lung Cancer in Women: An Adaptive Meta-analysis of Cohort Studies.
Synthesis in Journal of preventive medicine and public health = Yebang Uihakhoe chi, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Pooled it
- Pooled it
- Dietary intakes of citrus fruit and risk of gastric cancer incidence: an adaptive meta-analysis of cohort studies.Epidemiology and health · 2016Pooled it
- Lung cancer incidence and mortality in relationship to hormone replacement therapy use among women participating in the PLCO trial: a post hoc analysis.International journal of clinical oncology · 2020Trial
- Elevated risk of lung cancer among Asian American women who have never smoked: an emerging cancer disparity.Journal of the National Cancer Institute · 2025Article
- Reproductive factors and risk of lung cancer among 300,000 Chinese female never-smokers: evidence from the China Kadoorie Biobank study.BMC cancer · 2024Article
- Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper.BMJ open · 2021Article
- Epidemiology of lung cancer.Contemporary oncology (Poznan, Poland) · 2021Review
- Female reproductive factors and the risk of lung cancer in postmenopausal women: a nationwide cohort study.British journal of cancer · 2020Article
- Frailty Is Inversely Related to Age at Menopause and Elevated in Women Who Have Had a Hysterectomy: An Analysis of the Canadian Longitudinal Study on Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Perioperative outcome of lung cancer surgery in women: results from a Spanish nationwide prospective cohort study.Journal of thoracic disease · 2019Article
- We need to educate young lung cancer patients about menopause risk.Lung cancer management · 2019Article
- Biases Inherent in Studies of Coffee Consumption in Early Pregnancy and the Risks of Subsequent Events.Nutrients · 2018Review
- The epidemiology of lung cancer.Translational lung cancer research · 2018Review
- Influence of estrogen in non-small cell lung cancer and its clinical implications.Journal of thoracic disease · 2018Review
- Exploring estrogenic activity in lung cancer.Molecular biology reports · 2017Review
- Osteoporosis: Modern Paradigms for Last Century's Bones.Nutrients · 2016Review
- Citation Discovery Tools for Conducting Adaptive Meta-analyses to Update Systematic Reviews.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2016Article
- Human papillomavirus infection and risk of lung cancer in never-smokers and women: an 'adaptive' meta-analysis.Epidemiology and health · 2015Review
- Modifiable risk factors of lung cancer in "never-smoker" women.Epidemiology and health · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesApproximately 10% to 15% of lung cancer cases occur in never-smokers. Hormonal factors have been suggested to lead to an elevated risk of lung cancer in women. This systematic review (SR) aimed to investigate the association between hormonal replacement therapy (HRT) and the risk of lung cancer in women using cohort studies.
methodsWe first obtained previous SR articles on this topic. Based on these studies we made a list of refereed, cited, and related articles using the PubMed and Scopus databases. All cohort studies that evaluated the relative risk of HRT exposure on lung cancer occurrence in women were selected. Estimate of summary effect size (sES) with 95% confidence intervals (CIs) were calculated.
resultsA total of 14 cohort studies were finally selected. A random effect model was applied due to heterogeneity (I-squared, 64.3%). The sES of the 14 articles evaluating the impact of HRT exposure on lung cancer occurrence in women indicated no statistically significant increase in lung cancer risk (sES, 0.99; 95% CI, 0.90 to 1.09).
conclusionsThese results showed that HRT history had no effect on the risk of lung cancer in women, even though the sES of case-control studies described in previous SR articles indicated that HRT had a protective effect against lung cancer. It is necessary to conduct a pooled analysis of cohort studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.