ArticleScientific reports2015
Evolutionary conserved brainstem circuits encode category, concentration and mixtures of taste.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Decay chemicals activate a pH-sensing pathway to initiate a persistent state.bioRxiv : the preprint server for biology · 2026Article
- Gut distension evokes rapid neural dynamics in vagal and hindbrain populations of larval zebrafish.iScience · 2026Article
- Complex Sound Discrimination in Zebrafish: Auditory Learning Within a Novel "Go/Go" Decision-Making Paradigm.Animals : an open access journal from MDPI · 2025Article
- Understanding collective behavior through neurobiology.Current opinion in neurobiology · 2024Review
- Open source board based acoustofluidic transwells for reversible disruption of the blood-brain barrier for therapeutic delivery.Biomaterials research · 2023Article
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- Neurosensory development of the four brainstem-projecting sensory systems and their integration in the telencephalon.Frontiers in neural circuits · 2022Article
- Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain.Cell reports · 2021Article
- Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli.Current biology : CB · 2021Article
- Learning-dependent neuronal activity across the larval zebrafish brain.Current opinion in neurobiology · 2021Review
- Larval Zebrafish Use Olfactory Detection of Sodium and Chloride to Avoid Salt Water.Current biology : CB · 2021Article
- The Gut-Brain-Microbiome Axis and Its Link to Autism: Emerging Insights and the Potential of Zebrafish Models.Frontiers in cell and developmental biology · 2021Review
- Article
- The teleost fish, blue gourami Trichopodus trichopterus, distinguishes the taste of chemically similar substances.Scientific reports · 2020Article
- Sensing Senses: Optical Biosensors to Study Gustation.Sensors (Basel, Switzerland) · 2020Review
- Article
- The zebrafish subcortical social brain as a model for studying social behavior disorders.Disease models & mechanisms · 2019Review
- An Adult Brain Atlas Reveals Broad Neuroanatomical Changes in Independently Evolved Populations of Mexican Cavefish.Frontiers in neuroanatomy · 2019Article
- Primary sensory map formations reflect unique needs and molecular cues specific to each sensory system.F1000Research · 2019Review
- Imaging Neuronal Activity in the Optic Tectum of Late Stage Larval Zebrafish.Journal of developmental biology · 2018Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Evolutionary conserved brainstem circuits are the first relay for gustatory information in the vertebrate brain. While the brainstem circuits act as our life support system and they mediate vital taste related behaviors, the principles of gustatory computations in these circuits are poorly understood. By a combination of two-photon calcium imaging and quantitative animal behavior in juvenile zebrafish, we showed that taste categories are represented by dissimilar brainstem responses and generate different behaviors. We also showed that the concentration of sour and bitter tastes are encoded by different principles and with different levels of sensitivity. Moreover, we observed that the taste mixtures lead to synergistic and suppressive interactions. Our results suggest that these interactions in early brainstem circuits can result in non-linear computations, such as dynamic gain modulation and discrete representation of taste mixtures, which can be utilized for detecting food items at broad range of concentrations of tastes and rejecting inedible substances.
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